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Efficacy of ondansetron for the prevention of propofol injection pain: a meta-analysis

Authors Pei S, Zhou C, Zhu Y, Huang B

Received 29 November 2016

Accepted for publication 17 January 2017

Published 21 February 2017 Volume 2017:10 Pages 445—450

DOI https://doi.org/10.2147/JPR.S128992

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Lucy Goodman

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Enrica Santarcangelo

Shenglin Pei,1,* Chengmao Zhou,2,* Yu Zhu,2 Bing Huang 1

1Department of Anesthesiology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, 2Zhaoqing Medical College, Zhaoqing, People’s Republic of China

*These authors contributed equally to this work

Aim: This review was performed to investigate the effect of ondansetron on the prevention of propofol injection pain.
Methods: PubMed, Cochrane Library, and China National Knowledge Infrastructure (CNKI) were searched for randomized controlled trials (RCTs) of ondansetron in preventing the pain on injection of propofol. Then, RevMan 5.2 was adopted to conduct a meta-analysis on propofol injection pain.
Results: Ten RCTs, totaling 782 patients, were included in this analysis. The meta-analysis showed that: 1) compared with the control group, the ondansetron group was related to a decreasing incidence of propofol injection pain, and it was statistically significant (risk ratio [RR] = 0.41, 95% confidence interval [CI, 0.34, 0.49], P < 0.00001); 2) compared with the incidence of propofol injection pain in the lidocaine group, there was no difference and no statistical significance (RR = 1.28, 95% CI [0.85, 1.93], P = 0.25); 3) no statistically significant differences were found between the ondansetron and magnesium sulfate groups in the incidence of propofol injection pain (RR = 1.20, 95% CI [0.87, 1.66], P = 0.27); and 4) the incidence of ondansetron group igniting moderate pain (RR = 0.37, 95% CI [0.26, 0.52], P < 0.00001) and severe pain (RR = 0.27, 95% CI [0.17, 0.43] P < 0.00001) was less likely to occur during the injection of propofol compared with the control group, but there was no difference between the ondansetron and control groups in the incidence of mild propofol injection pain (RR = 0.83, 95% CI [0.63, 1.10], P = 0.20).
Conclusion: Ondansetron can effectively prevent propofol injection pain, and the effect is similar to that of magnesium sulfate and lidocaine.

Keywords: ondansetron, propofol injection pain, meta-analysis

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