Efficacy of micronutrient supplementation on skin aging and seasonal variation: a randomized, placebo-controlled, double-blind study

Ferial Fanian,^1,2 Sophie Mac-Mary,³ Adeline Jeudy,^1,2 Thomas Lihoreau,^1,2 Rafat Messikh,^1,2 Jean-Paul Ortonne,⁴ Jean-Marie Sainthillier,³ Ahmed Elkhyat,^1,2 Alexandre Guichard,^1,2 Kamran Hejazi Kenari,^1,2 Philippe Humbert<sup>1,2,5,6

1</sup>Center for Studies and Research on the Integument (CERT), Department of Dermatology, University Hospital of Besançon, Besançon, France; ²Clinical Investigation Center, CIC-BT 506, CHRU Besançon, France; ³SKINEXIGENCE, University Hospital of Jean Minjoz, Besançon, France; ⁴Department of Dermatology, University Hospital of L'archet, Nice, France; ⁵University of Franche-Comté, Besançon, France; ⁶INSERM 1098, Structure Fédérative de Recherche, Besançon, France


Background: Several studies have confirmed dramatic changes in skin surface parameters during the winter months. Although there are many studies supporting the positive effects of topical treatment, there are no published studies demonstrating the effects of oral supplementation in the prevention of negative skin changes during winter. The purpose of this study was to evaluate the efficacy of an oral micronutrient supplement in preventing the negative effects of winter weather on skin quality using noninvasive biometrologic instruments.
Methods: This study included 80 healthy female volunteers aged 35–55 years with phototype II–IV skin. Randomization was balanced. Two tablets of a micronutrient supplement (Perfectil^® Platinum) or placebo were administered once daily for 4 months. The volunteers were examined at baseline, after 4 months, and 6 weeks after termination of treatment (month 5.5). The evaluation included skin microrelief by Visioscan^® as the main outcome, and the secondary outcomes were results on standard macrophotography, skin tension by Reviscometer^®, skin high-frequency ultrasound, and self-assessment.
Results: For all pseudoroughness and microrelief indicators, there was a significant increase from baseline to month 4 in the placebo group (P<0.05) but no change in the active group. Descriptive statistics for the mean minimum, mean maximum, and minimum to maximum ratio on the nonexposed study zone showed a significant and dramatic difference between baseline and month 4 and between baseline and month 5.5 (P<0.05) in the active group, indicating decreasing anisotropy of the skin. High-frequency ultrasound on the exposed study zone revealed that skin thickness was significantly decreased in the placebo group during winter but was stable in the treated group (P<0.01). The photography scaling and self-assessment questionnaire revealed no significant changes in either group.
Conclusion: These results indicate that the skin is prone to seasonal changes during winter, particularly in exposed areas. The data also indicate that oral supplementation can be a safe treatment, with no serious side effects, and may prevent or even eliminate the negative effects of winter on the skin.

Keywords: oral supplementation, skin, elasticity, relief, high-frequency ultrasound, Reviscometer^®, Visioscan^®, nutraceuticals, winter variation