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Efficacy of ingenol mebutate gel for actinic keratosis in patients treated by thiazide diuretics

Authors Campione E, Di Prete M, Diluvio L, Bianchi L, Orlandi A

Received 24 April 2016

Accepted for publication 14 June 2016

Published 7 November 2016 Volume 2016:9 Pages 405—409

DOI https://doi.org/10.2147/CCID.S111305

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Jeffrey Weinberg


Elena Campione,1 Monia Di Prete,1 Laura Diluvio,1 Luca Bianchi,1 Augusto Orlandi2

1Department of Dermatology, 2Department of Pathology, University of Rome Tor Vergata, Rome, Italy


Abstract: Actinic keratosis (AK) is considered as superficial squamous cell carcinoma. Chronic sun exposure plays a central role in its pathogenesis. In particular, ultraviolet B radiation causes direct damage to the DNA, producing pyrimidine dimers that suppress the protective role of p53. Other risk factors include advanced age, male sex, and fair skin type. Even some drugs used for treating blood hypertension, such as thiazide diuretics, can increase the risk of developing AK. Their photosensitizing action seems to be connected with reactive oxygen species production. We report our experience on ten patients affected by multiple AK, in therapy with thiazide diuretics, treated by ingenol mebutate gel. AK was clinically and dermoscopically evaluated at baseline and after 30 days from the beginning of the treatment. Moreover, patients were screened for vitamin D3 values and reported a general hypovitaminosis status. To our knowledge, we report for the first time the efficacy of ingenol mebutate gel in this group of patients, particularly at risk of developing AK.

Keywords: anticancer agents, antitumor activity, cancer cells, skin precancerous lesion

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