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Efficacy of an acquainted drug in the treatment of inflammatory low back pain: sulfasalazine under investigation

Authors Moghimi J, Rezaei AA, Ghorbani R, Razavi M, Pahlevan D

Received 27 April 2016

Accepted for publication 4 August 2016

Published 23 September 2016 Volume 2016:10 Pages 3065—3069

DOI https://doi.org/10.2147/DDDT.S111568

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Wei Duan


Jamileh Moghimi,1 Ali Asghar Rezaei,2 Raheb Ghorbani,3 Mohammad Reza Razavi,4 Daryoush Pahlevan3

1Department of Rheumatology, Clinical Research Development Unit (CRDU), 2Clinical Research Development Unit (CRDU), Kowsar Hospital, 3Social Determinants of Health Research Center, Department of Community Medicine, Faculty of Medicine; 4Nursing Care Research Center, Student Research Committee, Semnan University of Medical Sciences, Semnan, Iran

Abstract: In the current study, the overall prevalence and the main underlying etiologies of inflammatory low back pain (ILBP) were determined, and the effectiveness of treatment with sulfasalazine was investigated in patients with inflammatory versus mechanical low back pain (LBP). In a prospective study conducted from July 2013 until August 2015, 1,779 consecutive patients within the age range of 18–50 years with a primary complaint of LBP referring to the rheumatology clinics were included. The patients were classified into two distinct groups: those suffering from ILBP (n=118) and those having mechanical LBP (n=1,661). Patients were followed-up for assessing the response rate to sulfasalazine with a mean follow-up time of 16 months. Results showed that among the total number of participants, 6.6% suffered from ILBP. The main underlying diagnoses of ILBP were undifferentiated spondyloarthropathy (USpA) (61.0%) and ankylosing spondylitis (24.6%). During the follow-up period, 3.4% of the participants had an appropriate response to only nonsteroidal anti-inflammatory drugs, 57.6% to sulfasalazine, 26.3% to addition of methotrexate to the previous regimen, and 12.7% to biological agents. Multiple logistic regression results showed that the underlying disease had a significant effect on the sulfasalazine response. The odds for response to treatment was 3.53 times higher in USpA patients compared to other patients (odds ratio =3.53, 95% confidence interval: 1.63–7.68, P=0.001). In 69.4% of the participants, the highest response to sulfasalazine was found, which was related to the underlying USpA. This study found that an adequate response to nonsteroidal anti-inflammatory drugs in patients with ILBP was potentially increased by adding sulfasalazine. Thus, the observed response rate was dependent on the nature of underlying spondyloarthropathy.

Keywords: low back pain, sulfasalazine, nonsteroidal anti-inflammatory drugs

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