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Efficacy of a repair cream containing Rhealba oat plantlets extracts, L-ALA-L-GLU dipeptide, and hyaluronic acid in wound-healing following dermatological acts: a meta-analysis of >2,000 patients in eight countries corroborated by a dermatopediatric clinical case

Authors Saint Aroman M, Guillot P, Dahan S, Coustou D, Mortazawi K, Zourabichvili O, Aardewijn T

Received 19 June 2018

Accepted for publication 27 September 2018

Published 13 November 2018 Volume 2018:11 Pages 579—589

DOI https://doi.org/10.2147/CCID.S177614

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Dr Jeffrey Weinberg


M Saint Aroman,1 P Guillot,2 S Dahan,3 D Coustou,3 K Mortazawi,4 O Zourabichvili,5 T Aardewijn1

1Pierre Fabre Dermo-Cosmétique, A-DERMA, Lavaur, France; 2Wallerstein Medico-Surgical Center, Dermatology Department, Arès, France; 3Saint-Jean du Languedoc Clinic, Dermatology Department, Toulouse, France; 4Clinic for Pediatric Surgery, Hospital Karlsruhe GmbH, Karlsruhe, Germany; 5Quanta Medical, Rueil-Malmaison, France

Background: The frequency of dermatological acts is increasing. These procedures often cause injuries and traumatic alterations in specific skin layers, slowing down wound healing.
Patients and methods: An open observational study lasting 1 month was conducted on 2,363 patients who had undergone various dermatological procedures. This study was conducted in eight European countries and an Asian country during which the tolerance and efficacy of a cosmetic cream based on Rhealba oat plantlets’ extract, l-ALA–l-GLU dipeptide, and hyaluronic acid were assessed on patients’ wounds.
Results: Efficacy was observed 5′ after the first application, which leads to an immediate relief, confirmed by the overall efficacy judged by the doctors as good or very good in 96.8% of the cases. In Germany, the efficacy of the same cream was assessed on children suffering from first- or second-degree burns. In this dermatopediatric case, the aim was to support the regeneration process and prevent scarring by using a topical cream rather than a silicon bandage or corticosteroids. A positive effect on skin regeneration and prevention of scaring could already be observed after 4 weeks of application without any undesired complication.
Conclusion: This clinical focus complements the previous meta-analysis by demonstrating that the tested cream containing Rhealba oat plantlets’ extracts, l-ALA–l-GLU dipeptide, and hyaluronic acid could also be used with a great efficacy in children after thermal burns to prevent scaring.

Keywords:
observational study, dermatology, meta-analysis, Rhealba oat plantlets’ extract, l-ALA–l-GLU dipeptide

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