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Efficacy and tolerability of liposomal polyvinylpyrrolidone-iodine hydrogel for the localized treatment of chronic infective, inflammatory, dermatoses: an uncontrolled pilot study

Authors Augustin M, Goepel L, Jacobi A, Bosse B, Mueller S, Hopp M

Received 16 May 2017

Accepted for publication 21 August 2017

Published 22 September 2017 Volume 2017:10 Pages 373—384


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Jeffrey Weinberg

Matthias Augustin,1 Lisa Goepel,2 Arnd Jacobi,2 Bjoern Bosse,3 Stefan Mueller,3 Michael Hopp3

1Department of Dermatology, University-Hospital Freiburg, Freiburg, 2Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf, University of Hamburg, Hamburg, 3Mundipharma Research GmbH & Co.KG, Limburg (Lahn), Germany

Abstract: Infection is common in many chronic, inflammatory skin conditions but is often difficult to treat, in part due to growing bacterial resistance to antibiotics. Liposomal polyvinylpyrrolidone (PVP)-iodine hydrogel has a unique mode of action, combining the antiseptic and anti-inflammatory actions of PVP-iodine with the drug delivery and moisturizing properties of liposomes. We investigated the utility of liposomal PVP-iodine to treat infective dermatoses. In this prospective, single-arm (uncontrolled), open-label Phase II pilot study, patients with acne vulgaris (n=30), atopic dermatitis (n=20), impetigo contagiosa (n=10), and rosacea (n=10) received PVP-iodine (3%) hydrogel for ≤4 weeks. Global Clinical Severity score improved for all dermatoses (range: 0.5 for acne vulgaris [p<0.001] to 1.0 for impetigo contagiosa [p=0.011]). Improvements in pain, quality of life, (Freiburg Life Quality Assessment), and Eczema Area and Severity Index scores were also seen. Treatment was well tolerated; most frequent adverse events were burning (14%) or itching (9%) sensations. Thus, liposomal PVP-iodine hydrogel has potential utility as an effective treatment for inflammatory skin conditions associated with bacterial colonization.

Keywords: acne vulgaris, atopic dermatitis, impetigo contagiosa, liposomal PVP-iodine hydrogel, polyvinylpyrrolidone, rosacea

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