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Efficacy and tolerability of agomelatine in the treatment of depression

Authors Plesničar BK

Received 24 December 2013

Accepted for publication 5 March 2014

Published 2 May 2014 Volume 2014:8 Pages 603—612

DOI https://doi.org/10.2147/PPA.S42789

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 5


Blanka Kores Plesničar

Ljubljana University Psychiatric Hospital, Ljubljana, Slovenia

Abstract: Depression is a severe and usually recurrent mental disorder which often leads to a significant impairment of everyday functioning, a reduced quality of life, and also great suffering of the patients. The treatment of a depressive disorder is not only limited to acute treatment; it also requires prolonged management. Patient compliance is of utmost importance. Unpleasant adverse effects and their impact on everyday living often lead to a premature discontinuation of antidepressant treatment and result in an unfavorable treatment outcome. The new antidepressant agomelatine, a melatonergic MT1/MT2 agonist and 5-HT2C receptor antagonist, has exhibited good antidepressant efficacy in acute, short-term, and long-term treatment. The adverse effect profile of agomelatine has been proven to be favorable and comparable to placebo, which is very important for good treatment compliance and adherence.

Keywords: agomelatine, circadian rhythms, depression


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