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Efficacy and safety of icotinib in patients with brain metastases from lung adenocarcinoma

Authors Xu J, Liu X, Yang S, Zhang X, Shi Y

Received 14 December 2015

Accepted for publication 10 March 2016

Published 17 May 2016 Volume 2016:9 Pages 2911—2917

DOI https://doi.org/10.2147/OTT.S102472

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 3

Editor who approved publication: Professor Min Li


Jianping Xu, Xiaoyan Liu, Sheng Yang, Xiangru Zhang, Yuankai Shi

Department of Internal Medicine, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China

Objective: The objective of this study was to evaluate the efficacy and safety of icotinib in patients with brain metastases (BMs) from lung adenocarcinoma.
Patients and methods: Clinical data of 28 cases with BMs from lung adenocarcinoma were retrospectively analyzed. All the patients took 125 mg icotinib orally three times a day. Progression of disease, intolerable adverse reactions, and number of deaths were recorded.
Results: For all the patients, the remission rate of icotinib was 67.8% and the disease control rate was 96.4%. The median overall survival time of patients was 21.2 months, and the median progression-free survival time of patients was 10.9 months. Only mild adverse events of grade 1/2 were observed during the treatment.
Conclusion: Icotinib was an effective and safe strategy to treat patients with BMs from lung adenocarcinoma.

Keywords: icotinib, lung adenocarcinoma, brain metastases

Corrigendum for this paper has been published.

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