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Efficacy and safety of fentanyl buccal for cancer pain management by administration through a soluble film: an update

Authors Delgado Guay M

Published 24 November 2010 Volume 2010:2 Pages 303—306

DOI https://doi.org/10.2147/CMAR.S7215

Review by Single-blind

Peer reviewer comments 2


Marvin Omar Delgado-Guay
Division of Geriatrics and Palliative Medicine, The University of Texas, Medical School at Houston, Houston, TX, USA

Abstract: More than half of patients receiving prescription medicine for cancer pain have been reported to experience inadequate pain relief or breakthrough pain. Buccal administration can deliver lipophilic opioids rapidly to the systemic circulation through the buccal mucosa, limiting gastrointestinal motility and first-pass metabolism. This review updates the safety and efficacy of fentanyl buccal soluble film (FBSF) in patients with cancer pain. Literature was identified through searches of Medline (PubMed). Search terms included combinations of the following: cancer pain, fentanyl, fentanyl buccal soluble film, pharmacology, kinetics, safety, efficacy and toxicity. FBSF is an oral transmucosal form of fentanyl citrate developed as a treatment of breakthrough pain in opioid-tolerant patients with cancer. Studies have shown that it is well tolerated in the oral cavity, with adequate bioavailability and safety in cancer patients. Further studies are warranted to evaluate, in comparison with other short-acting opioids, its efficacy in the management of breakthrough cancer pain, its addictive potential and its economic impact in cancer patients.

Keywords: fentanyl buccal soluble film, cancer pain

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