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Efficacy and safety of adalimumab in ankylosing spondylitis

Authors Mounach A, El Maghraoui A

Received 21 May 2014

Accepted for publication 16 July 2014

Published 13 August 2014 Volume 2014:6 Pages 83—90

DOI https://doi.org/10.2147/OARRR.S44550

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3


Aziza Mounach, Abdellah El Maghraoui

Rheumatology Department, Military Hospital Mohammed V, Rabat, Morocco

Abstract: Ankylosing spondylitis (AS) is the most common and most severe subtype of spondyloarthritis. It also may be an outcome of any of the other spondyloarthritis subtypes. AS preferentially affects the sacroiliac joints and the tip of the column, with a tendency to later ankylosis. Peripheral joints, enthesis, and other extra-articular involvement may be observed. Tumor necrosis factor (TNF) inhibitors are now well-established, effective drugs in the treatment of AS symptoms. Adalimumab, which is a fully human monoclonal antibody that binds to and neutralizes TNF, has demonstrated efficacy in treating AS symptoms, including axial involvement, peripheral arthritis, enthesitis, uveitis, gut involvement, and psoriasis. Furthermore, adalimumab has showed an overall acceptable safety profile. In this paper, we review the efficacy and safety profile of adalimumab in the treatment of AS, and discuss its differences from the other anti-TNF drugs reported in the literature.

Keywords: ankylosing spondylitis, spondyloarthritis, adalimumab, tumor necrosis factor-α

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