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Effects of vitamins C and D in type 2 diabetes mellitus

Authors Christie-David D, Girgis C, Gunton J

Received 24 September 2014

Accepted for publication 26 November 2014

Published 10 February 2015 Volume 2015:7 Pages 21—28

DOI https://doi.org/10.2147/NDS.S52022

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Chandrika Piyathilake

Darshika J Christie-David,1,2 Christian M Girgis,2–4 Jenny E Gunton1–4

1Department of Endocrinology and Diabetes, Westmead Hospital, 2Faculty of Medicine, University of Sydney, 3Westmead Millennium Institute, 4Garvan Institute of Medical Research, Sydney, NSW, Australia

Abstract: Scurvy and rickets are largely considered historical diseases in developed countries. However, deficiencies in vitamins C and D are re-emerging due to increased consumption of processed foods and reduced fresh foods in the Western diet, as well as to an indoor sedentary lifestyle away from sun exposure. These dietary and lifestyle factors also predispose one to diabetes and metabolic syndrome. Our understanding of the potential roles of vitamin C (an antioxidant) and vitamin D (a biologically active hormone) in disease is increasing. In this review, we present observational, interventional, and mechanistic studies that examine the potential links between vitamins C and D in reversing defects in glucose homeostasis and the prevention of type 2 diabetes. Studies suggest an association between vitamin C deficiency and diabetes. An association between vitamin D and insulin resistance has been well described; however, the role of vitamin C and D supplementation in diabetes and its prevention requires further controlled trials.

Keywords: glucose homeostasis, diabetes, insulin resistance, vitamin C, vitamin D


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