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Effects of sarpogrelate, eicosapentaenoic acid and pitavastatin on arterioslcerosis obliterans-related biomarkers in patients with type 2 diabetes (SAREPITASO study)

Authors Nomura S, Taniura T, Shouzu A, Omoto S, Suzuki M, Okuda Y, Ito T

Received 14 April 2018

Accepted for publication 3 July 2018

Published 18 September 2018 Volume 2018:14 Pages 225—232

DOI https://doi.org/10.2147/VHRM.S171143

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Cristina Weinberg

Peer reviewer comments 2

Editor who approved publication: Dr Naga Venkata Amarnath Kommuri


Shosaku Nomura,1 Takehito Taniura,2 Akira Shouzu,3 Seitaro Omoto,4 Masahiko Suzuki,5 Yoshinori Okuda,6 Tomoki Ito1

1First Department of Internal Medicine, Kansai Medical University, Hirakata, 2Division of Internal Medicine, Daiwa Hospital, Suita, 3Division of Internal Medicine, Saiseikai Izuo Hospital, Osaka, 4Division of Internal Medicine, Korigaoka Yukeikai Hospital, Hirakata, 5Division of Internal Medicine, Katano Hospital, Katano, 6Division of Internal Medicine, Meisei Memorial Hospital, Osaka, Japan

Background: The aim was to evaluate the significance of arteriosclerosis obliterans-related biomarkers in patients with type 2 diabetes mellitus (T2DM), and to compare the effects of sarpogrelate, eicosapentaenoic acid (EPA) and pitavastatin on these markers.
Patients and methods: Seventy-two arteriosclerosis obliterans patients with T2DM were classified into two groups, pitavastatin with either sarpogrelate (PS) or EPA (PE). We observed no differences in all biomarkers between the PS and PE groups before treatments.
Results: The levels of body mass index, hemoglobin A1c, soluble E-selectin, soluble vascular cell adhesion molecule 1, plasminogen activator inhibitor-1 and platelet-derived microparticle in the PE group decreased significantly after treatment. The ankle branchial pressure index and adiponectin levels significantly increased in the PE group after treatment compared with the PS group.
Conclusion: These results suggest that combination therapy using pitavastatin and EPA possesses an antiatherosclerotic effect and may be beneficial for prevention of vascular complications in patients with T2DM.

Keywords: T2DM, pitavastatin, sarpogrelate, eicosapentaenoic acid, EPA, adiponectin, platelet-derived microparticle, PDMP

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