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Effects of polymorphism in FABP2 Ala54Thr on serum lipids and glycemic control in low glycemic index diets are associated with gender among Han Chinese with type 2 diabetes mellitus

Authors Liu PJ, Liu YP, Qin HK, Xing T, Li SS, Bao YY

Received 2 December 2018

Accepted for publication 4 February 2019

Published 27 March 2019 Volume 2019:12 Pages 413—421

DOI https://doi.org/10.2147/DMSO.S196738

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Cristina Weinberg

Peer reviewer comments 2

Editor who approved publication: Professor Ming-Hui Zou


Peng Ju Liu,1,* Yan Ping Liu,1,* Hui Kun Qin,2 Tong Xing,2 Shan Shan Li,1 Yuan Yuan Bao1

1Departments of Clinical Nutrition, Peking Union Medical College Hospital, China Academic Medical Science and Peking Union Medical College, Beijing, People’s Republic of China; 2Department of Nutrition, Pinggu Hospital of Traditional Chinese Medicine, Beijing, People’s Republic of China

*These authors contributed equally to this work

Background/aims: Low glycemic index (GI) diets may have beneficial effects on glycemic control and serum lipid levels in patients with type 2 diabetes, but whether its effect is affected by polymorphisms of genes associated with lipid metabolism remains unclear. This study investigated whether the effects of a low-GI diet on serum lipids and glycemic control in patients with diabetes are associated with polymorphisms of FABP2 Ala54Thr (rs1799883).
Methods: A retrospective study was conducted involving 165 patients with type 2 diabetes mellitus (T2DM) who participated in two completed trials. Parameters reflecting the glycemic control, inflammatory factors, and fasting plasma lipids before and after intervention were measured, and the polymorphism of rs1799883 for each participant was genotyped using a MassARRAY. Differences between the genotypes of rs1799883 before or after the intervention were compared, and changes in the lipid profiles, glycemic control, inflammatory profiles, and dietary intake from baseline were analyzed using an analysis of covariance (generalized linear model).
Results: When the data were analyzed as a whole, after 4–5 weeks of similar low-GI diet intervention, we found that the decrease of triglycerides (TG) in the homozygous Ala54 carriers was more significant than that in the Thr54 allele carriers ([−0.58±1.24] vs [−0.14±1.08], P=0.015) with the adjustment for potential confounding factors; furthermore, compared with the Thr54 carriers, there was a significant trend in the decrease of total cholesterol (TC) in the homozygous Ala54 carriers (P=0.057). Subgroup analysis revealed that in women the homozygous Ala54 carriers exhibited a significant decrease of serum TG, TC, fasting blood glucose, and glycated albumin in women, but this was not noted in men.
Conclusion: The effect of FABP2 Ala54Thr polymorphism on response to blood lipids and glycemic control in low-GI diets is associated with gender among Han Chinese patients with T2DM.

Keywords: type 2 diabetes mellitus, plasma lipids, fatty acid-binding protein 2, single-nucleotide polymorphism, low glycemic index diet

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