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Effects of pitavastatin on plasminogen activator inhibitor-1 in hyperlipidemic patients

Authors Nomura S, Taniura, Shouzu, Omoto, Inami, Fujita S, Tamaki, Yokoi, Shimizu T, Ito

Received 1 March 2012

Accepted for publication 14 April 2012

Published 18 June 2012 Volume 2012:5 Pages 535—540

DOI https://doi.org/10.2147/IJGM.S31346

Review by Single-blind

Peer reviewer comments 3

Shosaku Nomura1, Takehito Taniura2, Akira Shouzu3, Seitarou Omoto4, Norihito Inami4, Shinya Fujita1, Takeshi Tamaki1, Takashi Yokoi1, Toshiki Shimizu1, Tomoki Ito1

1First Department of Internal Medicine, Kansai Medical University, Osaka, Japan; 2Department of Internal Medicine, Ueda Hospital, Osaka, Japan; 3Department of Internal Medicine, Saiseikai Izuo Hospital, Osaka, Japan; 4Second Department of Internal Medicine, Kansai Medical University, Osaka Japan

Abstract: The effects of statins on two platelet activation markers, plasiminogen activator inhibitor (PAI)-1 and adiponectin, were investigated in 68 patients with hyperlipidemia. The patients were treated with pitavastatin with a dosage of 2 mg daily. The plasma levels of platelet-derived microparticles (PDMP), soluble CD40 ligand (sCD40L), sP-selectin, PAI-1, and adiponectin were measured at baseline and after 6 months of treatment in both groups. In hyperlipidemic patients, the plasma levels were higher in PDMP, sCD40L, sP-selectin, and PAI-1, and lower in adiponectin, compared to the normolipidemic controls. Plasma PDMP and sCD40L were positively correlated, while plasma adiponectin was negatively correlated with the plasma levels of PAI-1. No significant differences were observed in the plasma levels of PDMP, sCD40L, sP-selectin, and PAI-1 before and after treatment. A significant increase in plasma adiponectin levels was observed after 6 months of treatment with pitavastatin. When the patients treated with pitavastatin were divided into two groups according to the adiponectin response to pitavastatin treatment, significant decreases in plasma PAI-1, PDMP, and sCD40L levels were observed after pitavastatin treatment in the responder group. These findings suggest that PDMP, sCD40L, and PAI-1 may participate in the development of atherothrombosis in patients with hyperlipidemia, and that pitavastatin may exert an adiponectin-dependent anti-atherothrombotic effect in hyperlipidemic patients.

Keywords: hyperlipidemia, PAI-1, pitavastatin, adiponectin, atherothrombosis

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