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Effects of pesticide exposure on reproductivity of male groundnut farmers in Kyauk Kan village, Nyaung-U, Mandalay region, Myanmar

Authors Zaw Lwin T, Than AA, Zaw Min A, Robson MG, Siriwong W

Received 24 May 2018

Accepted for publication 26 September 2018

Published 29 November 2018 Volume 2018:11 Pages 235—241

DOI https://doi.org/10.2147/RMHP.S175230

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Ms Justinn Cochran

Peer reviewer comments 3

Editor who approved publication: Dr Kent Rondeau


Thant Zaw Lwin,1,2 Aye Aye Than,3 Aung Zaw Min,4 Mark Gregory Robson,5 Wattasit Siriwong2,6

1Department of Preventive and Social Medicine, Defence Services Medical Academy, Yangon, Myanmar; 2Center for Risk Analysis and Health Surveillance (C-RAHS), College of Public Health Sciences, Chulalongkorn University, Bangkok, Thailand; 3Defence Services Orthopedics Hospital, Yangon, Myanmar; 4Military Institute of Nursing and Paramedical Sciences, Yangon, Myanmar; 5School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ, USA; 6College of Public Health Sciences, Chulalongkorn University, Bangkok, Thailand

Introduction: Kyauk Kan village of Nyaung-U, Mandalay region, Myanmar is one of the most famous groundnut-growing zones and has been exposed to pesticides.
Methods: This study design provided evaluation of within-person changes in the season across growing and nongrowing periods. A cross-sectional study was performed to identify health problems related to organophosphate pesticide (OP) exposure, to explore the protected use of this pesticide among 400 participants in the community by face-to-face interviews, and to determine the reproductive effects of OP exposure by using biomarkers of 100 male groundnut farmers aged 18–49 years.
Results: The mean age of the participants was 37.5±9.45 years. Analysis revealed statistically significant differences in seminal parameters (P<0.05 for pH, viscosity, motility, morphology, and sperm count) and in a reproductive hormonal assay (P<0.05 in follicle-stimulating hormone and testosterone) between the growing and nongrowing periods. Blood-cholinesterase levels of plasma cholinesterase in the growing period were significantly higher than those in the nongrowing period (P<0.05).
Conclusion: Our results suggest that chronic exposure related to OP dose may reduce potential male reproductivity.

Keywords: pesticide exposure, semen quality, serum hormone level, blood cholinesterase, male reproductivity

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