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Effects of LAMA/LABA Alone and in Combination on Cardiac Safety

Authors Andreas S

Received 17 January 2020

Accepted for publication 24 January 2020

Published 10 August 2020 Volume 2020:15 Pages 1931—1933


Checked for plagiarism Yes

Editor who approved publication: Dr Richard Russell

Stefan Andreas 1, 2

1Department of Cardiology and Pneumology, University Medical Centre Göttingen, Göttingen, Germany; 2LungClinic Immenhausen, Immenhausen, Germany, Member of the German Center for Lung Research (DZL)

Correspondence: Stefan Andreas
Department of Cardiology and Pneumology, Herzzentrum Gottingen, Robert-Koch-Str. 40, Göttingen, Germany
Tel +49 05673 501 1112
Fax +49 05673-501-1101

Chronic obstructive pulmonary disease (COPD) is a multidimensional, progressive condition characterized by airflow obstruction, worsening dyspnea and respiratory failure.1 The Global Initiative for Chronic Obstructive Lung Disease (GOLD) report suggests that long-acting β 2-agonists (LABAs) or long-acting muscarinic antagonists (LAMAs) are the preferred initial pharmacologic therapy option in the majority of patients with COPD, with escalation to dual therapy as required. 1
Extensive clinical data show that the LAMA tiotropium (SPIRIVA®; Boehringer Ingelheim Pharma GmbH, Ingelheim, Germany) delivered as a dry powder formulation by HandiHaler® (DPI; 18 μg nominal dose) or as an aqueous solution via the Respimat® Soft Mist™ inhaler (SMI; 5 μg nominal dose) can improve lung function, symptoms and outcomes, such as dyspnea and quality of life, and reduce exacerbations in patients with COPD. 2 Olodaterol (Striverdi®; Boehringer Ingelheim Pharma GmbH & Co K.G., Ingelheim, Germany) is a LABA that provides 24-hr bronchodilation, and has been shown to improve lung function and reduce symptoms in patients with COPD. 3 When given in a fixed-dose combination with tiotropium via the SMI (Spiolto®; Boehringer Ingelheim Pharma GmbH & Co K.G., Ingelheim, Germany), further improvements in lung function and health-related quality of life have been reported. 4

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