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Effects of fucoidan from Fucus vesiculosus in reducing symptoms of osteoarthritis: a randomized placebo-controlled trial

Authors Meyers S, Mulder A, Baker D, Robinson S, Rolfe M, Brooks L, Fitton J H

Received 26 August 2015

Accepted for publication 21 January 2016

Published 26 May 2016 Volume 2016:10 Pages 81—88


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Doris Benbrook

Stephen P Myers,1 Ann M Mulder,1 Don G Baker,1 Shelley R Robinson,1 Margaret I Rolfe,2 Lyndon Brooks,1 J Helen Fitton,3

NatMed-Research Unit, Southern Cross University, 2University Centre for Rural Health, Sydney School of Public Health, The University of Sydney, Lismore, NSW, 3Marinova Pty Ltd, Cambridge, TAS, Australia

Purpose: Preliminary investigation of a fucoidan with demonstrated reduction in the symptoms of osteoarthritis (OA) of the hip and knee.
Patients and methods: A double-blind randomized controlled trial was carried out to determine the safety and efficacy of a 300 mg dose of a Fucus vesiculosus extract (85% fucoidan) over a 12-week period in a population (n=122) with mild-to-moderate OA of the hip and knee as measured by the validated instrument "Comprehensive Osteoarthritis Test." Safety was measured by assessing cholesterol, liver function, renal function, and hematopoietic function, and closely monitoring adverse events.
Result: Ninety-six participants completed the study. The reduction in symptoms of OA was not significantly different from the placebo response. There were no changes in the blood measurements that were of any clinical significance during the course of the study.
Conclusion: The F. vesiculosus fucoidan extract was safe and well tolerated. At a dose of 300 mg, the extract showed no difference in reduction of OA symptoms from the placebo.

Keywords: joint pain, clinical trial, seaweed, polysaccharide

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