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Effects of early administration of insulin-like growth factor-1 on cognitive function in septic encephalopathy

Authors Yang Y, Liang S, Li Y, Gao F, Cao Y, Zhao X, Gao G, Li L

Received 14 October 2018

Accepted for publication 17 December 2018

Published 23 January 2019 Volume 2019:15 Pages 323—337

DOI https://doi.org/10.2147/NDT.S190845

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Ms Justinn Cochran

Peer reviewer comments 2

Editor who approved publication: Professor Jun Chen


Yang Yang,1,* Shengru Liang,2,* Yuqian Li,1,* Fei Gao,1 Yuan Cao,3 Xiaoyu Zhao,4 Guodong Gao,1 Lihong Li1

1Department of Neurosurgery, Tangdu Hospital, Air Force Medical University, Xi’an, Shaanxi Province 710038, China; 2Department of Endocrinology, Xijing Hospital, Air Force Medical University, Xi’an, Shaanxi Province 710032, China; 3Department of Neurosurgery, Xijing Hospital, Air Force Medical University, Xi’an, Shaanxi Province 710032, China; 4Department of Neurosurgery, The 986th Hospital of Chinese People’s Libertation Army, Xi’an, Shaanxi Province 710054, China

*These authors contributed equally to this work

Background: Both protective and therapeutic functions of insulin-like growth factor-1 (IGF-1) in brain injury have been reported, but its effects on cognitive sequelae after septic encephalopathy (SE) remain unclear.
Materials and methods: This study was divided into three parts, and a septic model was built by cecal ligation and puncture (CLP). First, survival analysis was performed, and IGF-1’s effects on long-term cognition and depressive emotion were assessed. Second, the characteristics of IGF-1 function in cognition were evaluated. Finally, cytochrome C, caspase-9, tumor necrosis factor receptor (TNFR), and caspase-8 levels as well as cell apoptosis in the hippocampus were evaluated.
Results: IGF-1 did not reduce mortality or alleviate depressive symptoms in septic rats, but improved the memory of noxious stimulation and spatial learning and memory. These effects were observed only when IGF-1 was administered within 0–6 hours after CLP. Moreover, cytochrome C and caspase-9 expression levels were increased at 6 hours after CLP in the hippocampus, while TNFR and caspase-8 amounts were not increased until 12 hours after CLP. Cell apoptosis increased at 12 hours after CLP, but was inhibited by IGF-1.
Conclusion: Cognitive impairment in rats recovering from SE is associated with cell apoptosis in the hippocampus. Supplementation of IGF-1 reduces cell apoptosis by preventing the over-expression of cytochrome C and TNFR, and results in improved cognitive function. However, improvement only occurs when IGF-1 is administered at the early stage (within 6 hours) of sepsis. As cytochrome C activation occurs earlier than that of TNFR in this study, cytochrome C may be the main factor inducing apoptosis in early SE.

Keywords: septic encephalopy, memory, learning, IGF-1, cytochrome C, TNFR, apoptosis


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