Effects of caffeic acid phenethyl ester on palatal mucosal defects and tooth extraction sockets

Ahmet Günay,¹ Osman Fatih Arpağ,² Serhat Atilgan,³ Ferhan Yaman,³ Yusuf Atalay,⁴ İzzet Acikan<sup>3

1</sup>Department of Periodontology, Faculty of Dentistry, Dicle University, Diyarbakir, Turkey; ²Department of Periodontology, Faculty of Dentistry, Mustafa Kemal University, Hatay, Turkey; ³Department of Maxillofacial Surgery, Faculty of Dentistry, Dicle University, Diyarbakir, Turkey; ⁴Department of Maxillofacial Surgery, Faculty of Dentistry, Kocatepe University, Afyon, Turkey

Aim: The purpose of this study was to evaluate the effects of caffeic acid phenethyl ester (CAPE) on palatal mucosal defects and tooth extraction sockets in an experimental model.
Materials and methods: Forty-two male Sprague-Dawley rats with a mean age of 7 weeks and weighing 280–490 g were used in this study. The rats were randomly divided into two groups: group A (the control group, n=21) and group B (the experimental group, n=21). Under anesthesia with ketamine (8 mg/100 g, intraperitoneally), palatal mucosal defects were created and tooth extraction was performed in the rats in groups A and B. Group A received no treatment, whereas group B received CAPE. CAPE was injected daily (10 µmol/kg, intraperitoneally). The rats were killed on days 7, 14, and 30 after the procedures. Palatal mucosa healing and changes in bone tissue and fibrous tissue were evaluated histopathologically.
Result: Pairwise comparisons showed no statistically significant difference between days 7 and 14 in either group (P>0.05). At day 30, bone healing was significantly better in group B (CAPE) than in group A (control) (P<0.05). Fibrinogen levels at day 30 were significantly higher in group A (control) than in group B (CAPE) (P<0.05). Pairwise comparisons showed no statistically significant difference in palatal mucosa healing levels between days 7 and 14 in both groups (P>0.05).
Conclusion: In conclusion, the findings of this study suggest that CAPE can significantly improve tooth socket healing.

Keywords: caffeic acid phenyl ester, palatal mucosa, tooth extraction socket, healing

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