Effects of Azelnidipine-Carboxymethylcellulose Gel on Healing of Full-Thickness Skin Wounds in Streptozotocin Induced Diabetic Rats
Received 29 July 2019
Accepted for publication 5 December 2019
Published 17 December 2019 Volume 2019:10 Pages 215—222
Checked for plagiarism Yes
Review by Single-blind
Peer reviewer comments 2
Editor who approved publication: Professor Young Lyoo
Mohammad Yasin Karami,1,2 Nasrin Mansournia,1 Neda Bagherian,3 Alireza Makarem,4 Nader MoeinVaziri,5 Sahar Borna,6 Amir Hossein Pourdavood,7 Iman Shamohammadi4
1Metabolic Disease Research Center, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran; 2Breast Disease Research Center, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; 3Department of Pediatrics, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; 4Department of Urology, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; 5Department of Surgery, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; 6Student Research Committee, Faculty of Medicine, Sari University of Medical Sciences, Sari, Iran; 7Department of Surgery, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran
Correspondence: Neda Bagherian
Department of Pediatrics, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Tel +98 9177021044
Objective: To evaluate the effects of azelnidipine-carboxyl methyl cellulose (AZL-CMC) gel and carboxyl methyl cellulose 2% gel (CMC) on the healing of full-thickness skin wounds of diabetic rats.
Methods: Fifteen Sprague Dawley male rats were studied. The rats were divided into three groups: AZL-CMC gel-treated, CMC 2% gel-treated, and control group. Wounds were assessed by wound area measurement every 3 days and histopathology samples were collected at 4, 7 and 12 days post wounding to evaluate the healing process using stereological study. Mann–Whitney U-test repeated measurement and non-parametric one-way analysis of variance (ANOVA) were used to analyze the data using SPSS, version 18.
Results: Numerical density of the fibroblasts of the AZL-CMC gel treated group was 59.17±2.69 (×104/mm3) and higher than the control 22.64±1.34 (×104/mm3) and CMC 2%-treated groups 40.80±5.27 (×104/mm3), respectively, PConclusion: The healing of AZL-CMC gel-treated wound was better than the control wounds, grossly. Wound healing processes and wound closure in the intervention group began sooner and was completed more quickly. The quantitative and qualitative parameters showed the significant wound healing effect of the AZL-CMC gel-treated group.
Keywords: wound healing, azelnidipine, streptozotocin, diabetic, rat
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