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Effects of an intrathecal TRPV1 antagonist, SB366791, on morphine-induced itch, body temperature, and antinociception in mice

Authors Sakakibara S, Imamachi N, Sakakihara M, Katsube Y, Hattori M, Saito Y

Received 28 May 2019

Accepted for publication 6 August 2019

Published 28 August 2019 Volume 2019:12 Pages 2629—2636

DOI https://doi.org/10.2147/JPR.S217439

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Nicola Ludin

Peer reviewer comments 3

Editor who approved publication: Dr E Alfonso Romero-Sandoval


Satoshi Sakakibara, Noritaka Imamachi, Manabu Sakakihara, Yukiko Katsube, Mai Hattori, Yoji Saito

Department of Anesthesiology, Shimane University Faculty of Medicine, Shimane, Japan

Correspondence: Noritaka Imamachi
Department of Anesthesiology, Shimane University Faculty of Medicine, 89-1 Enyacho Izumo, Shimane
693-8501, Japan
Tel +81 85 320 2295
Fax +81 85 320 2292
Email imamachi@med.shimane-u.ac.jp

Purpose: Transient receptor potential vanilloid 1 (TRPV1) not only is activated by multiple stimuli but also is involved with histamine-induced itch. The effects of TRPV1 on morphine-induced itch are unknown. We examined the effects of intrathecal administration of TRPV1 antagonist on morphine-induced itch, body temperature, and antinociception for mice.
Methods: Each C57/BL6j mouse was intrathecally administered with one of the following solutions: morphine, SB366791 (as the TRPV1 antagonist), morphine + SB366791, saline, or vehicle. For each mouse, each instance of observed scratching behavior was counted, the body temperature was measured, and the nociceptive threshold was determined using the tail-immersion test.
Results: SB366791 dose-dependently reduced the scratching behavior induced by the administration of morphine. SB366791 and the morphine + SB366791 groups did not manifest an increase in body temperature. Antinociceptive effects were observed to occur dose-dependently for morphine but not for SB366791. Compared with morphine alone, the administration of morphine + SB366791 did not reduce significant antinociceptive effects.
Conclusion: We propose that an intrathecal TRPV1 antagonist, SB366791, reduced morphine-induced itch without causing hyperthermia and did not suppress morphine-induced antinociception for mice.

Keywords: pruritus, opioid, TRPV1, nociception, hyperthermia

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