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Effectiveness of the cyclic administration of dienogest in a case of pathological disappearance of intestinal endometriosis

Authors Tamura R, Tsuneki I, Yanase T

Received 2 February 2013

Accepted for publication 9 March 2013

Published 16 July 2013 Volume 2013:5 Pages 421—424

DOI https://doi.org/10.2147/IJWH.S43567

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2


Ryo Tamura, Ikunosuke Tsuneki, Toru Yanase

Department of Obstetrics and Gynecology, Niigata City General Hospital, Niigata, Japan

Abstract: We have reported good control of atypical genital bleeding when using a cyclic administration of dienogest (repeated 4-week cycles, each consisting of the administration of 2 mg/day of dienogest for 3 weeks, followed by 1 week of drug withdrawal) in patients with endometriosis. Herein, we report the effectiveness of the long-term cyclic administration (22 months) of dienogest in a case of pathological disappearance of intestinal endometriosis diagnosed by endoscopy and histology of the lower gastrointestinal tract. There is no recurrent sign after 16 months of the treatment being stopped. Atypical genital bleeding during treatment was 3–5 days a month in each cycle. Compliance was good, so we could continue the therapy. The long-term cyclic administration of dienogest in patients with intestinal endometriosis may have significant merit.

Keyword: atypical genital bleeding, dysmenorrhea, drug compliance, endoscopy, histology

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