Back to Journals » Patient Preference and Adherence » Volume 13

Effectiveness of low-cost reminder package combined with case-based health education to improve hypertensive patients’ medication adherence: a clustered randomized controlled trial

Authors Shen Y, Wang T, Gao M, Zhu X, Zhang X, He C, Li Y, Sun X

Received 14 November 2018

Accepted for publication 30 May 2019

Published 10 July 2019 Volume 2019:13 Pages 1083—1092


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Naifeng Liu

Ying Shen,1 Taotao Wang,1 Min Gao,1 Xiaorou Zhu,1 Xing Zhang,1 Chao He,2 Yindong Li,2 Xinying Sun1

1School of Public Health, Peking University, Beijing, People’s Republic of China; 2Department of Health Education, Shunyi Center for Disease Control and Prevention, Beijing, People’s Republic of China

Purpose: Medication adherence (MA) is a key factor for hypertensive patients’ blood pressure control and forgetfulness is one of the main reasons that cause medication non-adherence. If effective, low-cost reminder package (LCRP) has great potentials for large-scale promotion. Therefore, this study aims to evaluate the effectiveness of combining LCRP and health education to improve MA among hypertensive patients.
Patients and methods: A clustered randomized controlled trial was performed in Beijing. A total of 518 hypertensive patients recruited from 8 community health care centers were randomized to receive LCRP combined with case-based health education or usual care. Randomization was performed at community level. Multilevel modeling was used to evaluate the study effect.
Results: MA scores did not differ significantly at baseline between the intervention group and the control group. The results of multilevel modeling indicated that MA scores increased more in the intervention group, and the intervention effect on MA was 0.287 (95% CI: [0.103, 0.471], P=0.002). Patients’ systolic blood pressure (SBP) and diastolic blood pressure (DBP) were not improved (SBP: difference=0.536, 95% CI [−3.207, 4.278]; DBP: difference=−0.927, 95% CI [−3.283, 1.428]).
Conclusion: LCRP combined with case-based health education could significantly improve hypertensive patients’ MA.

Keywords: low-cost reminder package, medication adherence, multilevel modeling, case-based health education

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]