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Effectiveness of afatinib after ineffectiveness of gefitinib in an advanced lung adenocarcinoma patient with a single EGFR exon 20 S768I mutation: a case report

Authors Duan H, Peng Y, Cui H, Qiu Y, Li Q, Zhang J, Shen W, Sun C, Luo C

Received 7 September 2017

Accepted for publication 16 January 2018

Published 23 April 2018 Volume 2018:11 Pages 2303—2309


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Faris Farassati

Hua Duan,1 Yanmei Peng,1 Huijuan Cui,2 Yuqin Qiu,1 Qiang Li,1 Jingyi Zhang,1 Wen Shen,1 Chenyao Sun,1 Chufan Luo1

1Department of China–Japan Friendship Hospital, Beijing University of Chinese Medicine, Beijing, China; 2Department of Oncology, China–Japan Friendship Hospital, Chaoyang, Beijing, China

Abstract: Epidermal growth factor receptor-tyrosine kinase inhibitors have improved progression-free survival and overall survival in non-small-cell lung cancer (NSCLC) patients with sensitive mutations. However, response of uncommon mutation to epidermal growth factor receptor-tyrosine kinase inhibitors is still unclear. S768I is one of the uncommon mutations.
A female patient with advanced NSCLC with a single S768I mutation achieved effectiveness from afatinib after showing no response to gefitinib. The patient had progression-free survival after taking afatinib for 6 months, and her follow-up is continuing. It suggests that afatinib may be a more effective treatment for NSCLC patients with a single S768I mutation, compared to first-generation tyrosine kinase inhibitors.

Keywords: NSCLC, epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs), S768I, afatinib, gefitinib

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