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Effect of the protein corona on nanoparticles for modulating cytotoxicity and immunotoxicity

Authors Lee YK, Choi EJ, Webster TJ, Kim SH, Khang D

Received 20 August 2014

Accepted for publication 10 November 2014

Published 18 December 2014 Volume 2015:10(1) Pages 97—113

DOI https://doi.org/10.2147/IJN.S72998

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 5

Editor who approved publication: Professor Carlos Rinaldi

Yeon Kyung Lee,1,* Eun-Ju Choi,2,* Thomas J Webster,3 Sang-Hyun Kim,4 Dongwoo Khang1

1Department of Molecular Medicine, School of Medicine, Gachon University, Incheon, South Korea; 2Division of Sport Science, College of Science and Technology, Konkuk University, Chungju, South Korea; 3Department of Chemical Engineering and Program in Bioengineering, Northeastern University, Boston, MA, USA; 4Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, South Korea

*These authors contributed equally to this work

Abstract: Although the cytotoxicity of nanoparticles (NPs) is greatly influenced by their interactions with blood proteins, toxic effects resulting from blood interactions are often ignored in the development and use of nanostructured biomaterials for in vivo applications. Protein coronas created during the initial reaction with NPs can determine the subsequent immunological cascade, and protein coronas formed on NPs can either stimulate or mitigate the immune response. Along these lines, the understanding of NP-protein corona formation in terms of physiochemical surface properties of the NPs and NP interactions with the immune system components in blood is an essential step for evaluating NP toxicity for in vivo therapeutics. This article reviews the most recent developments in NP-based protein coronas through the modification of NP surface properties and discusses the associated immune responses.

Keywords: nanostructured biomaterials, blood response, cytotoxicity, immunotoxicity, protein corona

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