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Effect of selenium nanoparticles with different sizes in primary cultured intestinal epithelial cells of crucian carp, Carassius auratus gibelio

Authors Wang YB, Yan XX, Fu LL

Received 18 July 2013

Accepted for publication 2 September 2013

Published 18 October 2013 Volume 2013:8(1) Pages 4007—4013

DOI https://doi.org/10.2147/IJN.S43691

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Yanbo Wang, Xuxia Yan, Linglin Fu

Marine Resources and Nutrition Biology Research Center, Food Quality and Safety Department, Zhejiang Gongshang University, Hangzhou, People's Republic of China

Abstract: Nano-selenium (Se), with its high bioavailability and low toxicity, has attracted wide attention for its potential application in the prevention of oxidative damage in animal tissues. However, the effect of nano-Se of different sizes on the intestinal epithelial cells of the crucian carp (Carassius auratus gibelio) is poorly understood. Our study showed that different sizes and doses of nano-Se have varied effects on the cellular protein contents and the enzyme activities of secreted lactate dehydrogenase, intracellular sodium potassium adenosine triphosphatase, glutathione peroxidase, and superoxide dismutase. It was also indicated that nano-Se had a size-dependent effect on the primary intestinal epithelial cells of the crucian carp. Thus, these findings may bring us a step closer to understanding the size effect and the bioavailability of nano-Se on the intestinal tract of the crucian carp.

Keywords: selenium nanoparticle, intestinal epithelial cell, crucian carp, primary culture

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