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Effect of Mental Health Problems on the Quality of Life in Children with Lupus Nephritis

Authors Putera AM, Irwanto I, Maramis MM, Prasetyo RV, Soemyarso NA, Noer MS

Received 18 February 2020

Accepted for publication 1 June 2020

Published 26 June 2020 Volume 2020:16 Pages 1583—1593


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Yuping Ning

Azwin Mengindra Putera,1 Irwanto Irwanto,1 Margarita Maria Maramis,2 Risky Vitria Prasetyo,1 Ninik Asmaningsih Soemyarso,1 Mohammad Sjaifullah Noer1

1Department of Child Health, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, Indonesia; 2Department of Psychiatry, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

Correspondence: Azwin Mengindra Putera
Department of Child Health, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital, Jl. Mayjen Prof. Dr. Moestopo No. 6– 8, Airlangga, Gubeng, Surabaya, East Java 60286, Indonesia
Tel +6231-5501218
Email [email protected]

Introduction: Mental health problems, such as anxiety, depression, and ineffective family coping, in children with lupus nephritis (LN) can increase the severity and affect the management of the disease, thus affecting the quality of life (QoL) of patients.
Objective: Analyzing the association between levels of depression, anxiety, coping, disease activity on the QoL of pediatric patients with LN.
Patients and Methods: There were 62 pediatric LN participants (16 participants in the induction phase and 46 participants in the maintenance phase). Participants were measured for anxiety, depression, coping, disease activity (systemic lupus erythematosus disease activity index/SLEDAI), and QoL. The measurement results were compared between induction and maintenance groups. Analysis of the association between anxiety, depression, coping, and disease activity with the QoL of children with LN used a multiple logistic regression test with p < 0.05.
Results:: The measurement results obtained anxiety (induction = 69.06± 3.92 and maintenance = 45.24± 10.33; p < 0.001), depression (induction = 69.88± 3.34 and maintenance = 42.20± 9.12; p < 0.001), coping (induction = 99.88± 12.93 and maintenance = 115.67± 7.34; p < 0.001), SLEDAI (induction = 15.81± 12.58 and maintenance = 0.43± 1.26; p < 0.001), and QoL (induction = 49.92± 12.44 and maintenance = 88.15± 8.06; p < 0.001).. Anxiety level in the induction group (p = 0.043) and maintenance group (p < 0.001; p = 0.032; p = 0.008; p = 0.009). Depression level in the induction group (p = 0.031) and maintenance group (p = 0.024; p = 0.042; p = 0.003). SLEDAI score in the maintenance group (p = 0.003; p = 0.003). Coping in induction group (p = 0.016; p = 0.016) and maintenance group (p = 0.005).
Conclusion: Mental health disorders reduce the QoL of LN children, and the level of QoL in induction phase is lower than maintenance phase.

Keywords: anxiety, depression, disease activity, coping, quality of life, lupus nephritis

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