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Effect of intrathecal dexmedetomidine on cesarean section during spinal anesthesia: a meta-analysis of randomized trials

Authors Wang YQ, Zhang XJ, Wang Y

Received 20 March 2019

Accepted for publication 8 August 2019

Published 21 August 2019 Volume 2019:13 Pages 2933—2939


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Qiongyu Guo

Yun-Qi Wang,1,2 Xian-Jie Zhang,1 Ying Wang1

1Department of Anesthesiology, People’s Hospital of Deyang City, Sichuan, People’s Republic of China; 2Department of Anesthesiology, The Sixth People’s Hospital of Deyang City, Sichuan, People’s Republic of China

Correspondence: Ying Wang
Department of Anesthesiology, People’s Hospital of Deyang City, No. 173, Section 1, Taishan North Road, Deyang City, Sichuan Province, People’s Republic of China

Objective: Intrathecal dexmedetomidine has been used in spinal anesthesia during cesarean sections. The purpose of this meta-analysis was to investigate the effect of intrathecal dexmedetomidine on the adverse reactions of spinal anesthesia during cesarean section.
Methods: We searched for relevant studies using PubMed, Web of Science, and the Cochrane library. After screening studies and extracting data, we performed a meta-analysis on the effect of intrathecal dexmedetomidine during cesarean section.
Results: A total of 278 patients from 4 studies were included in this meta-analysis. The incidence of shivering in the dexmedetomidine groups was significantly lower than that in the placebo groups during cesarean section (RR=0.40, 95% CI [0.25, 0.65], P=0.0002). Intrathecal dexmedetomidine had no effect on nausea and vomiting (RR=1.08, 95% CI [0.68, 1.71], P=0.74), bradycardia (RR=1.33, 95% CI [0.31, 5.76], P=0.70), and hypotension during cesarean section (RR=0.78, 95% CI [0.59, 1.03], P=0.08).
Conclusion: Intrathecal dexmedetomidine can effectively reduce the occurrence of shivering during cesarean section, but it does not affect the occurrence of nausea and vomiting, bradycardia or hypotension.

Keywords: dexmedetomidine, cesarean section, spinal anesthesia, adverse reactions

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