Back to Journals » Drug Design, Development and Therapy » Volume 13

Effect of intrathecal dexmedetomidine on cesarean section during spinal anesthesia: a meta-analysis of randomized trials

Authors Wang YQ, Zhang XJ, Wang Y

Received 20 March 2019

Accepted for publication 8 August 2019

Published 21 August 2019 Volume 2019:13 Pages 2933—2939

DOI https://doi.org/10.2147/DDDT.S207812

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Qiongyu Guo


Yun-Qi Wang,1,2 Xian-Jie Zhang,1 Ying Wang1

1Department of Anesthesiology, People’s Hospital of Deyang City, Sichuan, People’s Republic of China; 2Department of Anesthesiology, The Sixth People’s Hospital of Deyang City, Sichuan, People’s Republic of China

Correspondence: Ying Wang
Department of Anesthesiology, People’s Hospital of Deyang City, No. 173, Section 1, Taishan North Road, Deyang City, Sichuan Province, People’s Republic of China
Email 459088699@qq.com

Objective: Intrathecal dexmedetomidine has been used in spinal anesthesia during cesarean sections. The purpose of this meta-analysis was to investigate the effect of intrathecal dexmedetomidine on the adverse reactions of spinal anesthesia during cesarean section.
Methods: We searched for relevant studies using PubMed, Web of Science, and the Cochrane library. After screening studies and extracting data, we performed a meta-analysis on the effect of intrathecal dexmedetomidine during cesarean section.
Results: A total of 278 patients from 4 studies were included in this meta-analysis. The incidence of shivering in the dexmedetomidine groups was significantly lower than that in the placebo groups during cesarean section (RR=0.40, 95% CI [0.25, 0.65], P=0.0002). Intrathecal dexmedetomidine had no effect on nausea and vomiting (RR=1.08, 95% CI [0.68, 1.71], P=0.74), bradycardia (RR=1.33, 95% CI [0.31, 5.76], P=0.70), and hypotension during cesarean section (RR=0.78, 95% CI [0.59, 1.03], P=0.08).
Conclusion: Intrathecal dexmedetomidine can effectively reduce the occurrence of shivering during cesarean section, but it does not affect the occurrence of nausea and vomiting, bradycardia or hypotension.

Keywords: dexmedetomidine, cesarean section, spinal anesthesia, adverse reactions

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]