Effect of dexamethasone on the IGFBP-1 regulation in premature infants during the first weeks of life

Axel Dost, Eberhard Kauf, Dorothea Schlenvoigt, Dirk Schramm, Felix Zintl, Axel Hübler

Department of Pediatrics, Friedrich-Schiller-University, Jena, Germany

Background: Early glucosteroid treatment in preterm infants has a negative impact on physical growth and development. So far, data on dexamethasone effect on the GH/IGF axis and the clinical outcome are conflicting.

Objective: Therefore, we studied the effect of dexamethasone treatment on parameters of somatic growth and on the secretion of insulin like growth factors (IGFs) and insulin like growth factors binding proteins (IGFBPs) in preterm infants.

Methods: In 75 preterm infants somatic development was assessed at birth and after 3 months of corrected age. IGF-I/II and IGFBP-1-3 were measured at the same time. According to their treatment regime the infants were assigned to the dexamethasone treated or the non-treated group.

Results: At 3 months the 13 infants with dexamethasone had a lower body weight, slightly lower body length and a lower head circumference. IGF-II (464.4 ± 97.4 vs 638 ± 201.4 µg/l, p = 0.001) and IGFBP-3 (1800 ± 426 vs 2105 ± 547 µg/l, p = 0.045) were significantly reduced under the influence of glucocorticoids, whereas IGFBP-1 was elevated (59.6 ± 61.0 vs 21.1 ± 21.7 µg/l, p = 0.002). The ratio IGFBP-3/(IGFBP-1 + 2) was reduced in the dexamethasone group (1.827 ± 0.868 vs 3.098 ± 1.898 µg/l, p = 0.016), implying a significant retardation in the somatic development.

Conclusion: Dexamethasone impairs IGF and IGFBP secretion and stimulates IGFBP-1, an inhibitor of IGF-I. These pathways might contribute to alterations of the GH/IGF axis, particularly the ratio IGFBP-3/(IGFBP-1 + 2).

Keywords: dexamethasone, IGF, IGFBP-1, preterm infants, growth