Back to Journals » Neuropsychiatric Disease and Treatment » Volume 11

Effect of depressive symptoms on the length of hospital stay among patients hospitalized for acute stroke in Japan

Authors Sugawara N, Metoki N, Hagii J, Saito S, Shiroto H, Tomita T, Yasujima M, Okumura K, Yasui-Furukori N, Sawada K

Received 28 June 2015

Accepted for publication 7 September 2015

Published 5 October 2015 Volume 2015:11 Pages 2551—2556


Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Prof. Dr. Roumen Kirov

Peer reviewer comments 2

Editor who approved publication: Professor Wai Kwong Tang

Norio Sugawara,1 Norifumi Metoki,2 Joji Hagii,2 Shin Saito,2 Hiroshi Shiroto,2 Tetsu Tomita,1 Minoru Yasujima,2 Ken Okumura,3 Norio Yasui-Furukori1

1Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki, Japan; 2Hirosaki Stroke and Rehabilitation Center, Hirosaki, Japan; 3Department of Cardiology, Hirosaki University School of Medicine, Hirosaki, Japan

Background: Depression after stroke is one of the most serious complications of stroke. Although many studies have shown that the length of hospital stay (LOHS) is a measurable and important stroke outcome, research has found limited evidence concerning the effect of depression on LOHS among patients who have experienced acute stroke. The objective of this study was to assess the effect of depression on LOHS among patients hospitalized for acute ischemic stroke in Japan.
Methods: We retrospectively examined 421 patients who had experienced acute ischemic stroke. Stroke severity was measured by the National Institutes of Health Stroke Scale (NIHSS) on the 7th day of hospitalization. On the 10th day of hospitalization, depressive symptoms and functional assessment were assessed by the Japan Stroke Scale (Depression Scale) and the Functional Independence Measure, respectively. A general linear model was employed to assess the effect of probable depression on LOHS.
Results: The prevalence of probable depression in the current sample was 16.3% in males and 17.8% in females. The mean LOHS of participants with probable depression (76.4±49.2 days) was significantly longer than that of participants without probable depression (44.9±39.2 days). An analysis using the general linear model to assess the effect on LOHS revealed a significant interaction between the presence of probable depression and NIHSS scores.
Conclusion: Depression after stroke was associated with significant increases in LOHS. Early detection and treatment for depression are necessary for patients with ischemic stroke.

Keywords: poststroke depression, length of hospital stay, ischemic stroke, Japanese

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]


Other articles by this author:

Application of a stratum-specific likelihood ratio analysis in a screen for depression among a community-dwelling population in Japan

Sugawara N, Kaneda A, Takahashi I, Nakaji S, Yasui-Furukori N

Neuropsychiatric Disease and Treatment 2017, 13:2369-2374

Published Date: 12 September 2017

Work–family conflict as a mediator between occupational stress and psychological health among mental health nurses in Japan

Sugawara N, Danjo K, Furukori H, Sato Y, Tomita T, Fujii A, Nakagami T, Kitaoka K, Yasui-Furukori N

Neuropsychiatric Disease and Treatment 2017, 13:779-784

Published Date: 13 March 2017

Attitudes toward metabolic adverse events among patients with schizophrenia in Japan

Sugawara N, Yasui-Furukori N, Yamazaki M, Shimoda K, Mori T, Sugai T, Matsuda H, Suzuki Y, Minami Y, Ozeki Y, Okamoto K, Sagae T, Someya T

Neuropsychiatric Disease and Treatment 2016, 12:427-436

Published Date: 24 February 2016

Parental bonding and attitudes toward suicide among medical college students in Japan

Hashimoto K, Sugawara N, Tanaka O, Nakamura K, Yasui-Furukori N

Neuropsychiatric Disease and Treatment 2014, 10:2015-2020

Published Date: 23 October 2014

A positive correlation between serum amyloid β levels and depressive symptoms among community-dwelling elderly individuals in Japan

Tsuruga K, Sugawara N, Yasui-Furukori N, Takahashi I, Tsuchimine S, Kaneda A, Nakaji S, Nakamura K

Neuropsychiatric Disease and Treatment 2014, 10:1621-1627

Published Date: 30 August 2014

Comparison of predictive equations for resting energy expenditure among patients with schizophrenia in Japan

Sugawara N, Yasui-Furukori N, Tomita T, Furukori H, Kubo K, Nakagami T, Kaneko S

Neuropsychiatric Disease and Treatment 2014, 10:427-432

Published Date: 28 February 2014

Readers of this article also read:

Green synthesis of water-soluble nontoxic polymeric nanocomposites containing silver nanoparticles

Prozorova GF, Pozdnyakov AS, Kuznetsova NP, Korzhova SA, Emel’yanov AI, Ermakova TG, Fadeeva TV, Sosedova LM

International Journal of Nanomedicine 2014, 9:1883-1889

Published Date: 16 April 2014

Methacrylic-based nanogels for the pH-sensitive delivery of 5-Fluorouracil in the colon

Ashwanikumar N, Kumar NA, Nair SA, Kumar GS

International Journal of Nanomedicine 2012, 7:5769-5779

Published Date: 15 November 2012

A novel preparation method for silicone oil nanoemulsions and its application for coating hair with silicone

Hu Z, Liao M, Chen Y, Cai Y, Meng L, Liu Y, Lv N, Liu Z, Yuan W

International Journal of Nanomedicine 2012, 7:5719-5724

Published Date: 12 November 2012

Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy

Deepa G, Thulasidasan AK, Anto RJ, Pillai JJ, Kumar GS

International Journal of Nanomedicine 2012, 7:4077-4088

Published Date: 27 July 2012

Crystallization after intravitreal ganciclovir injection

Pitipol Choopong, Nattaporn Tesavibul, Nattawut Rodanant

Clinical Ophthalmology 2010, 4:709-711

Published Date: 14 July 2010