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Effect of coffee (caffeine) against human cataract blindness

Authors Varma S

Received 15 September 2015

Accepted for publication 6 November 2015

Published 27 January 2016 Volume 2016:10 Pages 213—220

DOI https://doi.org/10.2147/OPTH.S96394

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Gokcen Gökçe

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser


Shambhu D Varma

Department of Ophthalmology and Visual Sciences, Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA

Abstract: Previous biochemical and morphological studies with animal experiments have demonstrated that caffeine given topically or orally to certain experimental animal models has significant inhibitory effect on cataract formation. The present studies were undertaken to examine if there is a correlation between coffee drinking and incidence of cataract blindness in human beings. That has been found to be the case. Incidence of cataract blindness was found to be significantly lower in groups consuming higher amounts of coffee in comparison to the groups with lower coffee intake. Mechanistically, the caffeine effect could be multifactorial, involving its antioxidant as well as its bioenergetic effects on the lens.

Keywords: caffeine, cataract, cataract blindness, cataractogenic process, intraocular pressure, vision impairment

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