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Effect of blood type on survival of Chinese patients with esophageal squamous cell carcinoma

Authors Qin J, Wu S, Sun J, Lin H, He Z, Li Q

Received 31 January 2015

Accepted for publication 18 March 2015

Published 23 April 2015 Volume 2015:8 Pages 947—953

DOI https://doi.org/10.2147/OTT.S81936

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Editor who approved publication: Professor Daniele Santini

Jian Qin,1,* San-Gang Wu,2,* Jia-Yuan Sun,3 Huan-Xin Lin,3 Zhen-Yu He,3 Qun Li3

1Department of Radiation Oncology of Clinical Cancer Center, the People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, People’s Republic of China; 2Department of Radiation Oncology, Xiamen Cancer Center, the First Affiliated Hospital of Xiamen University, Xiamen, People’s Republic of China; 3Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Department of Radiation Oncology, Collaborative Innovation Center of Cancer Medicine, Guangzhou, People’s Republic of China

*These authors contributed equally to this work

Background: The aim of this study was to evaluate the prognostic value of ABO blood group in Chinese patients with esophageal squamous cell carcinoma (ESCC) after esophagectomy.
Methods: This study was a retrospective review of the records of 548 patients with ESCC who received cytoreductive surgery between October 2002 and March 2007. The prognostic impact of ABO blood group on overall survival (OS) was analyzed.
Results: The median follow-up time was 37 months, and the 5-year OS was 43.3%. The overall 5-year OS was 41.2%, 49.7%, 44.0%, and 29.8% for the A, B, O, and AB groups, respectively (P=0.038). Among patients with negative lymph nodes (LNs), the 5-year OS was 59.0%, 68.2%, 57.9%, and 28.6% for the A, B, O, and AB groups, respectively (P<0.001), but blood type had no value in predicting the OS of patients with positive LNs (P=0.524). In multivariate Cox regression analysis of all patients, ABO blood group was not an independent prognostic factor of OS. However, in patients with negative LNs, blood type was an independent prognostic factor of OS, and the higher risk of death for patients of type AB versus non-AB significant in multivariate analyses (hazard ratio [HR], 2.576; 95% confidence interval [CI], 1.349–4.919; P=0.004).
Conclusion: ABO blood group is associated with survival in Chinese patients with ESCC. Patients with blood type AB had a significantly worse OS than patients with non-AB type, especially in patients with negative LNs.

Keywords: esophageal squamous cell carcinoma, ABO blood-group system, prognosis, lymph node, survival
 

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