Back to Journals » Journal of Experimental Pharmacology » Volume 11

Effect of Bitter Melon on Spatial Memory of Rats Receiving a High-Fat Diet

Authors Sepehri H, Hojati A, Safari R

Received 16 September 2019

Accepted for publication 13 November 2019

Published 10 December 2019 Volume 2019:11 Pages 115—119


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Professor Bal Lokeshwar

Hamid Sepehri,1 Arefeh Hojati,2 Razieh Safari3

1Neuroscience Research Center, Golestan University of Medical Sciences, Gorgan, Iran; 2Department of Physiology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran; 3Medical Cellular and Molecular Research Center, Golestan University of Medical Sciences, Gorgan, Iran

Correspondence: Hamid Sepehri
Neuroscience Research Center, Golestan University of Medical Sciences, Gorgan, Iran

Introduction: Momordica charantia or bitter melon is a tropical vine of the family Cucurbitaceous widely grown in India. Its fruits have potent anti-oxidant properties due to the presence of tannins, vitamin C and flavonoids. There is much evidence it protects cognitive function and cholesterol level. In addition, there are reports of the effect of a high-fat diet (HFD)on memory. In this study, the effect of bitter melon on spatial memory in rats, following an HFD, in a water maze was examined.
Material and methods: In this study, 28 male Wistar rats aged 10 weeks and weighing between 180 and 250 grams were divided into four groups (N=7). Control, High-fat, High-fat + bitter melon, and bitter melon. The control group was fed a standard rat diet, whereas the high-fat groups were fed the same standard diet containing 5% cholesterol for eight weeks, and the treated group received, in addition, 1 g/kg bitter melon fruit powder in their diet, Learning and spatial memory were evaluated by using a Morris Water Maze (MWM) for a six-day period, including five days of training, the last day was the test day (probe day).
Results: The high-fat group was fed a high-fat diet for two months, this resulted in reduced learning ability;, this group took longer and travelled a longer distance compared to the control group. However, the administration of bitter melon improved memory function only in the high-fat group.
Conclusion: The administration of bitter melon improves spatial-memory performance in rats receiving an HFD.

Keywords: bitter melon, high-fat diet, water maze

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]