Effect of Benzo[a]pyrene-DNA Adduct in Cord Blood on the Neurodevelopment of 12-Month-Old Infants in Qingdao City
Received 12 June 2019
Accepted for publication 4 November 2019
Published 2 December 2019 Volume 2019:15 Pages 3351—3357
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Prof. Dr. Roumen Kirov
Peer reviewer comments 2
Editor who approved publication: Dr Yuping Ning
Yong Zhang,1,* Yuehua Yang,2,* Qian Zhang,3,* Jing Cui,4 Abdul Rahaman,5 Xiao-Rong Huang,6,7 Ya Su,4 Ruqin Gao,4 Bingling Wang,4 Zulqarnain Baloch6
1Department of Paediatric Surgery, Qingdao Women and Children’s Hospital, Qingdao, People’s Republic of China; 2Department of Obstetrics, The Affiliated Central Hospital of Qingdao University, Qingdao, People’s Republic of China; 3Department of Child Health Care, Huangdao Maternity and Child Health Care Hospital of Qingdao, Qingdao, People’s Republic of China; 4Department of Environmental Health, Qingdao Centers for Disease Control and Prevention/Qingdao Institute for Preventive Medicine, Qingdao, People’s Republic of China; 5School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, People’s Republic of China; 6Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, People’s Republic of China; 7College of Veterinary Medicine, South China Agricultural University, Guangzhou, 51062, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Zulqarnain Baloch
Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, People’s Republic of China
Department of Environmental Health, Qingdao Institute for Preventive Medicine, No. 175 Shandong Road, Qingdao 266033, People’s Republic of China
Tel +86 532 85621975
Fax +86 532 85623909
Introduction: The study was designed to explore the possible adverse effects of prenatal polycyclic aromatic hydrocarbons (PAHs) on the neurodevelopment of the infants at the age of 12 months in a birth cohort in Qingdao of China. Benzo[a]pyrene (BaP)-DNA adduct level in umbilical cord blood was measured by enzyme immunoassay.
Methods: Child neurodevelopment was assessed at both 6 months and 12 months of age using the Gesell Development Inventory (GDI).
Results: This study results reveal that multivariate linear analysis, cord BaP-DNA adduct level was inversely associated with developmental quotient score in the adaptive domain [β = −0.08; 95% CI: (−0.16, −0.003); p = 0.04], gross motor domain [β = −0.10; 95% CI: (−0.20, −0.01); p = 0.02], fine motor domain [β = −0.15; 95% CI: (−0.25, −0.05); p = 0.01], language domain [β = −0.12; 95% CI: (−0.21, −0.03); p = 0.02], and personal–social domain [β = −0.13; 95% CI: (−0.22, −0.04); p<0.01]. Further, multivariate logistic regression analysis showed increased cord BaP-DNA adduct levels associated with increased odds of delayed in language domain.
Conclusion: In conclusion, the study suggested that prenatal PAH exposure monitored by umbilical cord blood BaP-DNA adducts may adversely affect the neurodevelopment of the infants at 12 months of age.
Keywords: neurodevelopment, PAH-DNA adducts, infant, polycyclic aromatic hydrocarbons, China
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