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Effect of administration of water enriched in O2 by injection or electrolysis on transcutaneous oxygen pressure in anesthetized pigs

Authors Charton A, Péronnet F, Doutreleau S, Lonsdorfer E, Klein A, Jimenez L, Geny B, Diemunsch P, Richard R

Received 15 April 2014

Accepted for publication 16 May 2014

Published 26 August 2014 Volume 2014:8 Pages 1161—1167

DOI https://doi.org/10.2147/DDDT.S66236

Checked for plagiarism Yes

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Peer reviewer comments 2

Antoine Charton,1 François Péronnet,2 Stephane Doutreleau,3 Evelyne Lonsdorfer,3 Alexis Klein,4 Liliana Jimenez,4 Bernard Geny,3 Pierre Diemunsch,1 Ruddy Richard5

1Department of Anesthesia and Critical Care, and EA 3072, Hôpital de Hautepierre; University of Strasbourg, Strasbourg, France; 2Department of Kinesiology, Université de Montréal, Montreal, QC, Canada; 3CHRU of Strasbourg, Physiology and Functional Explorations Department, New Civil Hospital, Strasbourg, France and University of Strasbourg, Faculty of Medicine, Physiology Department, Strasbourg, France; 4Danone Research, Palaiseau, France; 5Department of Sport Medicine and Functional Explorations, CHU Clermont-Ferrand and INRA UMR 1019, CRNH-Auvergne, Clermont-Ferrand, France

Background: Oral administration of oxygenated water has been shown to improve blood oxygenation and could be an alternate way for oxygen (O2) supply. In this experiment, tissue oxygenation was compared in anesthetized pigs receiving a placebo or water enriched in O2 by injection or a new electrolytic process.
Methods: Forty-two pigs randomized in three groups received either mineral water as placebo or water enriched in O2 by injection or the electrolytic process (10 mL/kg in the stomach). Hemodynamic parameters, partial pressure of oxygen in the arterial blood (PaO2), skin blood flow, and tissue oxygenation (transcutaneous oxygen pressure, or TcPO2) were monitored during 90 minutes of general anesthesia. Absorption and tissue distribution of the three waters administered were assessed using dilution of deuterium oxide.
Results: Mean arterial pressure, heart rate, PaO2, arteriovenous oxygen difference, and water absorption from the gut were not significantly different among the three groups. The deuterium to protium ratio was also similar in the plasma, skin, and muscle at the end of the protocol. Skin blood flow decreased in the three groups. TcPO2 slowly decreased over the last 60 minutes of the experiment in the three groups, but when compared to the control group, the values remained significantly higher in animals that received the water enriched in O2 by electrolysis.
Conclusions: In this protocol, water enriched in O2 by electrolysis lessened the decline of peripheral tissue oxygenation. This observation is compatible with the claim that the electrolytic process generates water clathrates which trap O2 and facilitate O2 diffusion along pressure gradients. Potential applications of O2-enriched water include an alternate method of oxygen supply.

Keywords: transcutaneous oxygen partial pressure determination, tissue oxygenation, oxygenated water, water clathrate
 

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Other article by this author:

Apparent Km of mitochondria for oxygen computed from Vmax measured in permeabilized muscle fibers is lower in water enriched in oxygen by electrolysis than injection

Zoll J, Bouitbir J, Sirvent P, Klein A, Charton A, Jimenez L, Péronnet FR, Geny B, Richard R

Drug Design, Development and Therapy 2015, 9:3589-3597

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