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Ectopic micronodular thymoma with lymphoid stroma in the cervical region: a rare case associated with Langerhans cells proliferation

Authors Yu M, Meng Y, Xu B, Zhao L, Zhang Q

Received 18 April 2016

Accepted for publication 9 June 2016

Published 18 July 2016 Volume 2016:9 Pages 4317—4322

DOI https://doi.org/10.2147/OTT.S110802

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 3

Editor who approved publication: Professor Min Li


Min Yu,1 Yuan Meng,2 Bin Xu,2 Lin Zhao,3 Qingfu Zhang4

1Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, People’s Republic of China; 2Department of Pathology, Fushun Central Hospital, Fushun, People’s Republic of China; 3Second Department of Medical Oncology, The General Hospital of Fushun Mining Bureau, Fushun, People’s Republic of China; 4Department of Pathology, College of Basic Medical Sciences, China Medical University, Shenyang, People’s Republic of China

Abstract: Micronodular thymoma (MNT) with lymphoid stroma is a rare thymic epithelial neoplasm with the characteristics of multiple nodules separated by abundant lymphoid stroma. MNTs mainly arise in the anterior mediastinum and thymus, while ectopic MNTs are extremely rarely seen. Here, we report an ectopic MNT that occurred in the neck of a 62-year-old woman. There were also scattered eosinophilic granulocytes and S100+/CD1a+ Langerhans cells within the tumor. This case provides a better understanding of such rare, poorly understood cases.

Keywords: ectopic, micronodular thymoma, lymphoid stroma, Langerhans cell

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