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Early Study of Tumor Abnormal Protein in Gastric Adenocarcinoma

Authors Zhang M, Wang X, Wang Z

Received 15 December 2020

Accepted for publication 13 February 2021

Published 5 March 2021 Volume 2021:14 Pages 1719—1726

DOI https://doi.org/10.2147/OTT.S297413

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Nicola Silvestris


Ming Zhang,* Xiaoyu Wang,* Zhenghua Wang

Department of Gastrointestinal Oncology (Ward I), The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, 121000, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Zhenghua Wang
Department of Gastrointestinal Oncology (Ward I), The First Affiliated Hospital of Jinzhou Medical University, No. 2, Section 5, Renmin Street, Jinzhou, Liaoning, 121000, People’s Republic of China
Email [email protected]

Objective: To study the correlation between tumor abnormal protein (TAP) and tumor markers, blood glucose, uric acid and coagulation function in gastric adenocarcinoma and to evaluate the clinical application of TAP in the diagnosis of gastric adenocarcinoma.
Methods: A total of 34 nontumor patients and 95 gastric adenocarcinoma patients admitted to the First Affiliated Hospital of Jinzhou Medical University were enrolled in this study. Fresh blood from patients’ fingertips was collected, all blood samples were examined with TAP testing kit, and then searched and measured the condensed particulate matter.
Results: The comparison of TAP between nontumor patients and gastric adenocarcinoma patients was statistically significant (P< 0.05). Bivariate correlation analysis was conducted between TAP and other related tumor markers (alpha-fetoprotein, carcinoembryonic antigen, carbohydrate antigen 19– 9 (CA199), carbohydrate antigen 72– 4 (CA72-4)), blood glucose, uric acid, and coagulation function-related indicators, and the results showed that the correlation between TAP and CA199, CA72-4, and activated partial prothrombin time was statistically significant. In addition, according to the analysis results, there was no significant difference among TAP and age, height and weight in the tumor population and the nontumor population.
Conclusion: TAP can be used for the screening and diagnosis of gastric adenocarcinoma, and the effect of TAP combined with other indicators is more significant than TAP alone.

Keywords: tumor abnormal protein, gastric adenocarcinoma, tumor markers, blood glucose, uric acid, coagulation function

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