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Durvalumab for the management of urothelial carcinoma: a short review on the emerging data and therapeutic potential

Authors Baldini C, Champiat S, Vuagnat P, Massard C

Received 2 December 2018

Accepted for publication 1 February 2019

Published 3 April 2019 Volume 2019:12 Pages 2505—2512


Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 4

Editor who approved publication: Dr Sanjeev Srivastava

Capucine Baldini, Stéphane Champiat, Perrine Vuagnat, Christophe Massard

Drug Development Department, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France

Abstract: Urothelial carcinoma (UC) is the second most frequent urogenital malignancy with high incidence in the United States and Europe. Despite poor prognosis, new treatments have emerged with great efficacy and safety such as immune checkpoint inhibitors. Durvalumab, an anti Programmed Death Ligand 1, has been given breakthrough in UC in 2017 in patients who have disease progression during or following platinum-containing chemotherapy or who have disease progression

Keywords: immunotherapy, PD-L1 inhibitor, durvalumab, urothelial carcinoma, bladder cancer

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