Dupilumab-Associated Blepharoconjunctivitis with Giant Papillae
Authors Vingopoulos F, Lazzaro DR
Received 19 May 2020
Accepted for publication 26 June 2020
Published 28 July 2020 Volume 2020:13 Pages 303—305
Checked for plagiarism Yes
Review by Single-blind
Peer reviewer comments 2
Editor who approved publication: Dr Scott Fraser
Filippos Vingopoulos, Douglas R Lazzaro
New York University School of Medicine, Department of Ophthalmology, New York, NY 10017, USA
Correspondence: Douglas R Lazzaro
New York University School of Medicine, Department of Ophthalmology, 222 East 41st Street, 4th Floor, New York, NY 10017, USA
Tel +1 (929) 455-5051
Purpose: To describe a case of severe dupilumab-associated blepharoconjunctivitis with giant papillae treated with high potency corticosteroid eyedrops, without discontinuing or reducing dupilumab therapy.
Case Report: A 22-year-old Latin American female with a long history of severe atopic dermatitis (AD) with no ocular involvement presented 20 weeks after starting treatment with dupilumab injections with blurry vision, multiple chalazia, eyelid swelling and severe conjunctival injection in both eyes. She also reports having a hordeolum 2 months prior and severely dry eyes starting 2 weeks prior. Slit-lamp examination revealed severe conjunctivitis with macroscopically visible giant papillae in the right lower tarsal conjunctiva. The diagnosis of severe dupilumab-associated blepharoconjunctivitis was made and difluprednate 0.05% eyedrops two times a day for 7 days was initiated. Given the severity of her AD and her marked skin improvement with dupilumab, it was decided to continue dupilumab without reducing the dose. At 2-day follow-up, conjunctival injection had markedly improved, and at 2-month follow-up, her examination was unremarkable. Currently, our patient only uses dexamethasone 0.1% drops few times a week as per needed for occasional eye irritation.
Conclusion: As dupilumab injections begin to claim a rightful place in medicine, the ophthalmic community may start encountering dupilumab-associated ocular surface disease all more often and potentially play an important role in identifying, characterizing and treating the adverse ocular effects from this novel medication.
Keywords: dupilumab, blepharoconjunctivitis, conjunctivitis, atopic dermatitis, dupilumab adverse reactions
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