Dual-drug nanomedicine with hydrophilic F127-modified magnetic nanocarriers assembled in amphiphilic gelatin for enhanced penetration and drug delivery in deep tumor tissue
Authors Lai Y, Chiang C, Kao TH, Chen S
Received 2 January 2018
Accepted for publication 28 March 2018
Published 22 May 2018 Volume 2018:13 Pages 3011—3026
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Eytan Klausner
Peer reviewer comments 2
Editor who approved publication: Dr Lei Yang
Yen-Ho Lai, Chih-Sheng Chiang, Tzu-Hsun Kao, San-Yuan Chen
Department of Materials Science and Engineering, National Chiao Tung University, Hsinchu, Taiwan, Republic of China
Introduction: Deep penetration of large-sized drug nanocarriers into tumors is important to improve the efficacy of tumor therapy.
Methods: In this study, we developed a size-changeable “Trojan Horse” nanocarrier (THNC) composed of paclitaxel (PTX)-loaded Greek soldiers (GSs; ~20 nm) assembled in an amphiphilic gelatin matrix with hydrophilic losartan (LST) added.
Results: With amphiphilic gelatin matrix cleavage by matrix metalloproteinase-2, LST showed fast release of up to 60% accumulated drug at 6 h, but a slow release kinetic (~20%) was detected in the PTX from the GSs, indicating that THNCs enable controllable release of LST and PTX drugs for penetration into the tumor tissue. The in vitro cell viability in a 3D tumor spheroid model indicated that the PTX-loaded GSs liberated from THNCs showed deeper penetration as well as higher cytotoxicity, reducing a tumor spheroid to half its original size and collapsing the structure of the tumor microenvironment.
Conclusion: The results demonstrate that the THNCs with controlled drug release and deep penetration of magnetic GSs show great potential for cancer therapy.
Keywords: amphiphilic gelatin, nanocarriers, controlled release, deep tumor penetration
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