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Dry eye disease ranking among common reasons for seeking eye care in a large US claims database

Authors Bradley JL, Özer Stillman I, Pivneva I, Guerin A, Evans AM, Dana R

Received 25 September 2018

Accepted for publication 17 December 2018

Published 1 February 2019 Volume 2019:13 Pages 225—232

DOI https://doi.org/10.2147/OPTH.S188314

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser


John L Bradley,1,2 Ipek Özer Stillman,3 Irina Pivneva,4 Annie Guerin,4 Amber M Evans,5 Reza Dana6

1Naval Medical Research Unit Dayton, Vision Science Lab, Wright Patterson AFB, OH, USA; 2University of Pikeville, Kentucky College of Optometry, Pikeville, KY, USA; 3Takeda, Lexington, MA, USA; 4Analysis Group, Inc, Montreal, QC, Canada; 5Health ResearchTx LLC, Trevose, PA, USA; 6Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA

Objectives: Dry eye disease (DED) is a complex multifactorial condition of the ocular surface characterized by symptoms of ocular discomfort, irritation, and visual disturbance. Data previously reported from this study showed an increase in prevalence and incidence of DED with age and over time. The objective of this study was to compare the ranking of DED prevalence among other ocular conditions that led patients to seek eye care.
Methods: In this population-based study using the US Department of Defense Military Health System claims database of >9.7 million beneficiaries, indicators of DED and other ocular conditions were analyzed over time. The overall prevalence (2003–2015) and annual incidence (2008–2012) of DED and other ocular conditions were estimated using an algorithm based on two independent indicators derived from selected diagnostic and procedure codes and prescriptions for cyclosporine ophthalmic emulsion for DED and diagnostic codes for the indicators of other common ocular conditions.
Results: In 2003–2015, the most common ocular conditions were disorders of refraction and accommodation (25.84%), cataracts (17.14%), glaucoma (7.27%), disorders of the conjunctiva (6.76%), other retinal disorders (5.94%), and DED (5.28%). DED was the fifth most prevalent ocular condition in women (7.78%) and ninth most prevalent in men (2.96%). In 2012, DED had the third highest annual incidence (0.87%), behind disorders of refraction/accommodation (1.87%) and cataracts (1.50%).
Conclusion: This study provided further epidemiologic evidence for DED as a commonly occurring condition that drives patients to seek treatment.

Keywords: DED, epidemiology, prevalence, incidence


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