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Drug-eluting Bead-Transcatheter Arterial Chemoembolization for Advanced Hepatocellular Carcinoma Refractory to Conventional Lipiodol-based Transcatheter Arterial Chemoembolization

Authors Kobayashi S, Tajiri K, Murayama A, Entani T, Futsukaichi Y, Nagata K, Takahashi K, Yasuda I

Received 25 July 2020

Accepted for publication 3 September 2020

Published 14 October 2020 Volume 2020:7 Pages 181—189


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Ahmed Kaseb

Saito Kobayashi, Kazuto Tajiri, Aiko Murayama, Toshiki Entani, Yuka Futsukaichi, Kohei Nagata, Kosuke Takahashi, Ichiro Yasuda

Department of Gastroenterology, Toyama University Hospital, Toyama, Japan

Correspondence: Kazuto Tajiri
Department of Gastroenterology, Toyama University Hospital, 2630 Sugitani, Toyama 930-0194, Japan
Tel +81-76-434-7301
Fax +81-76-434-5027

Purpose: To evaluate the potential of drug-eluting bead (DEB)-transcatheter arterial chemoembolization (TACE) as a treatment option for patients with refractory to conventional lipiodol-based TACE (c-TACE) especially with decreased liver function.
Patients and Methods: We retrospectively evaluated the treatment results of DEB-TACE for 89 HCC nodules in 27 patients with c-TACE refractory according to liver function.
Results: Although overall survival was significantly better in Child–Pugh A patients than in Child–Pugh B patients (median survival time, MST: 561 vs 347 days, p=0.031), progression-free survival was almost similar in both patients between Child–Pugh A and B (MST: 79 vs 87 days, p=0.534). Regarding antitumor response, the objective response rate (ORR) and disease-control rate (DCR) were 5.3/12.5% and 52.7/87.5% in Child–Pugh A/B, respectively. In each 89 HCC nodules, ORR and DCR were almost similar between Child–Pugh A and B (ORR, 20.3 vs 13.3%; DCR, 77.0 vs 73.3%, respectively). Adverse events of DEB-TACE were well-tolerated, and liver function was reserved during DEB-TACE procedures.
Conclusion: DEB-TACE could be a therapeutic option for advanced HCC patients with c-TACE refractory and decreased liver function.

Keywords: TACE-refractory, drug-eluting bead, post-embolization syndrome, microsphere, tyrosine kinase inhibitor

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