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Downregulation of Proline Hydroxylase 2 and Upregulation of Hypoxia-Inducible Factor 1α are Associated with Endometrial Cancer Aggressiveness

Authors Zhu C, Ding H, Yang J, Zhou Y, Luo Y, Shi S, Zhang Y, Wei Y, Ni G

Received 16 July 2019

Accepted for publication 30 October 2019

Published 22 November 2019 Volume 2019:11 Pages 9907—9912

DOI https://doi.org/10.2147/CMAR.S223421

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Antonella D'Anneo


Chengcheng Zhu,1 Huafeng Ding,1 Junwen Yang,1 Yihui Zhou,1 Yonghong Luo,1 Suhua Shi,1 Ying Zhang,1 Yalan Wei,2 Guantai Ni1

1Departments of Gynecology and Obstetrics, Yi Jishan General Hospital of Wannan Medical College, Wuhu, Anhui, People’s Republic of China; 2Departments of Gynecology and Obstetrics, General Hospital of Wuhu Second People’s Hospital, Wuhu, Anhui, People’s Republic of China

Correspondence: Guantai Ni; Yalan Wei
Departments of Gynecology and Obstetrics, Yi Jishan General Hospital of Wannan Medical College, 2 Zheshan West Road, Wuhu, Anhui 241000, People’s Republic of China
Tel +86-138 5532 0259
Email 12sunhl14@163.com; 603329457@qq.com

Introduction: Proline hydroxylase 2 (PHD2) is involved in tumorigenesis. This study aimed to examine PHD2 and hypoxia-inducible factor 1α (HIF-1α) expression in different endometrial tissues and explore the correlations between PHD2 and HIF-1α expression with clinicopathological characteristics of endometrial cancer.
Methods: We collected 50 tissue sections of endometrial adenocarcinoma, 30 of atypical endometrial hyperplasia, and 30 of control normal endometrium. The expression of PHD2 was detected by PCR, Western blot, and immunohistochemical analysis.
Results: PHD2 mRNA and protein levels reduced in endometrial cancer tissues compared to normal endometrium (p<0.05). In contrast, HIF-1α expression levels increased in endometrial cancer tissues compared to normal endometrium (p<0.05). In addition, PHD2 and HIF-1α levels were correlated with lymphovascular stromal invasion (LVSI), postoperative FIGO stage, and lymph node metastasis of endometrial cancer (p<0.05).
Conclusion: Our findings suggest that reduced expression of PHD2 and increased expression of HIF-1α are associated with endometrial cancer aggressiveness. PHD2 might be a novel biomarker and a potential target for endometrial cancer management.

Keywords: proline hydroxylase, hypoxia-inducible factor, endometrial cancer, prognosis

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