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Does the Autophagy Related Gene 7 (ATG7) Have a Role in Non-Melanoma Skin Cancer?

Authors Samaka RM, Basha MA, Mansour E

Received 5 July 2019

Accepted for publication 29 November 2019

Published 20 January 2020 Volume 2020:13 Pages 49—58

DOI https://doi.org/10.2147/CCID.S222051

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Jeffrey Weinberg


Rehab M Samaka, 1 Mohammed A Basha, 2 Eman Mansour 3

1Pathology Department, Faculty of Medicine, Menoufia University, Al Minufya, Egypt; 2Dermatology, Andrology and STDs Department, Faculty of Medicine, Menoufia University, Al Minufya, Egypt; 3Ministry of Health, El Menshawy General Hospital, Tanta, Egypt

Correspondence: Eman Mansour
Ministry of Health, El Menshawy General Hospital, Tanta, Egypt
Tel +201273906558
Fax +20403305158
Email htmsecti20@gmail.com

Rehab M Samaka
Pathology Department, Faculty of Medicine, Menoufia University, Al Minufya, Egypt
Tel +201002806239
Fax +20482317508
Email Rehabsamaka@yahoo.com

Purpose: To evaluate the role of autophagy related gene 7 (ATG7) in non-melanoma skin cancer.
Subjects and Methods: This retrospective and prospective case-control study was performed on 104 patients with non-melanoma skin cancer (NMSC) in addition to 20 apparently healthy subjects matched for age and sex as a control group. Multiple skin biopsies were taken for immunohistochemical evaluation of ATG7 expression.
Results: Both epithelial and stromal ATG7 were expressed in all participants while all patients showed nucleocytoplasmic localization and controls showed both cytoplasmic and nucleocytoplasmic expression. In addition, significantly higher H-scores of ATG7 in both epithelium and stroma were detected in patients compared to controls (P< 0.001).
Conclusion: ATG7 nucleocytoplasmic topographic localization might be involved in the pathogenesis of NMSC, which can open the gate for new target therapy for this skin cancer.

Keywords: autophagy, autophagy related gene 7, BCC, SCC, NMSC

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