Back to Journals » Therapeutics and Clinical Risk Management » Volume 4 » Issue 5

Docetaxel in the treatment of squamous cell carcinoma of the head and neck

Authors Alexander Rapidis, Nicholas Sarlis, Jean-Louis Lefebvre, Merrill Kies

Published 10 October 2008 Volume 2008:4(5) Pages 865—886

DOI https://doi.org/10.2147/TCRM.S3133

Review by Single-blind

Peer reviewer comments 2

Alexander Rapidis1, Nicholas Sarlis2, Jean-Louis Lefebvre3, Merrill Kies4

1Department of Maxillofacial Surgery, Greek Anticancer Institute, Saint Savvas Hospital, Athens, Greece; 2Department of Medical Affairs, Oncology – US Sanofi-Aventis, Bridgewater, NJ, USA; 3Head and Neck Department, Centre Régional de Lutte Contre le Cancer de Lille, Lille, France; 4Department of Thoracic/Head and Neck Medical Oncology, The University of Texas – M.D. Anderson Cancer Center, Houston, TX, USA

Abstract: Squamous cell carcinoma of the head and neck (SCCHN) presents at a locally advanced (LA) stage in many patients. Chemotherapy has been successfully integrated into first-line treatment programs, either during or prior to radiotherapy (RT) – the cornerstone modality for local disease control of inoperable disease or when organ preservation is desired. Concomitant chemoradiotherapy (CCRT) provides an absolute survival benefit when compared with other types of locoregional therapy that exclude chemotherapy. Nonetheless, distant metastases still represent the most common cause of treatment failure. Consequently, adding induction chemotherapy (ICT) to definitive non-surgical local therapies with a curative intent has been vigorously explored in LA SCCHN. Recently, it has been shown that ICT using the combination of the taxane docetaxel with cisplatin–5-fluorouracil provides significant survival benefit over cisplatin–5-FU, when used before either definitive RT (TAX323 trial) or carboplatin-based CCRT (TAX324 trial). Docetaxel is also being investigated in metastatic or recurrent (M/R) disease, with promising initial results. It is very likely that the future management strategies of SCCHN will incorporate biologic agents as an add-on to docetaxel-containing schemas, administered either as ICT prior to CCRT in the LA setting or for the management of M/R disease.

Keywords: chemoradiotherapy, chemotherapy, docetaxel, head and neck carcinoma, induction, locally advanced, taxane

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF] 

 

Other article by this author:

Erratum

Rapidis A, Sarlis N, Lefebvre J-L, et al

Therapeutics and Clinical Risk Management 2008, 4:1381-1381

Published Date: 5 December 2008

Readers of this article also read:

Unusual case of contralateral Horner's syndrome following stellate-ganglion block: a case report and review of the literature

Amhaz HH, Manders L, Chidiac EJ, Pallekonda V, Chakrabortty S

Local and Regional Anesthesia 2013, 6:31-33

Published Date: 10 October 2013

Effect of intratumoral administration on biodistribution of 64Cu-labeled nanoshells

Xie H, Goins B, Bao A, Wang ZJ, Phillips WT

International Journal of Nanomedicine 2012, 7:2227-2238

Published Date: 3 May 2012

Treatment patterns and risk factor control in patients with and without metabolic syndrome in cardiac rehabilitation

Gitt A, Jannowitz C, Karoff M, Karmann B, Horack M, Völler H

Vascular Health and Risk Management 2012, 8:265-274

Published Date: 24 April 2012

Inflammatory mechanisms in the lung

B Moldoveanu, P Otmishi, P Jani, J Walker, X Sarmiento, et al

Journal of Inflammation Research 2009, 2:1-11

Published Date: 16 December 2008

Vinflunine in the treatment of bladder cancer

Mark Bachner, Maria De Santis

Therapeutics and Clinical Risk Management 2008, 4:1243-1253

Published Date: 5 December 2008

Editorial  ||FREE PAPER||

Garry M Walsh

Therapeutics and Clinical Risk Management 2008, 4:0-0

Published Date: 6 June 2008

Update on local anesthetics: focus on levobupivacaine

Crina L Burlacu, Donal J Buggy

Therapeutics and Clinical Risk Management 2008, 4:381-392

Published Date: 11 April 2008