Back to Journals » Neuropsychiatric Disease and Treatment » Volume 11

Disturbed spontaneous brain activity pattern in patients with primary angle-closure glaucoma using amplitude of low-frequency fluctuation: a fMRI study

Authors Huang X, Zhong Y, Zeng X, Zhou F, Liu X, Hu P, Pei C, Shao Y, Dai X

Received 29 April 2015

Accepted for publication 8 June 2015

Published 29 July 2015 Volume 2015:11 Pages 1877—1883

DOI https://doi.org/10.2147/NDT.S87596

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Prof. Dr. Roumen Kirov

Peer reviewer comments 3

Editor who approved publication: Professor Wai Kwong Tang

Xin Huang,1,* Yu-Lin Zhong,1,* Xian-Jun Zeng,2 Fuqing Zhou,2 Xin-Hua Liu,1 Pei-Hong Hu,1 Chong-Gang Pei,1 Yi Shao,1 Xi-Jian Dai2

1Department of Ophthalmology, 2Department of Radiology, The First Affiliated Hospital of Nanchang University, Nangchang, Jiangxi, People’s Republic of China

*These authors contributed equally to this work

Objective: The aim of this study is to use amplitude of low-frequency fluctuation (ALFF) as a method to explore the local features of spontaneous brain activity in patients with primary angle -
closure glaucoma (PACG) and ALFFs relationship with the behavioral performances.
Methods: A total of twenty one patients with PACG (eight males and 13 females), and twenty one healthy subjects (nine males and twelve females) closely matched in age, sex, and education, each underwent a resting-state functional magnetic resonance imaging scan. The ALFF method was used to assess the local features of spontaneous brain activity. The correlation analysis was used to explore the relationships between the observed mean ALFF signal values of the different areas in PACG patients and the thickness of the retinal nerve fiber layer (RNFL).
Results: Compared with the healthy subjects, patients with PACG had significant lower ALFF areas in the left precentral gyrus, bilateral middle frontal gyrus, bilateral superior frontal gyrus, right precuneus, and right angular gyrus, and higher areas in the right precentral gyrus. In the PACG group, there were significant negative correlations between the mean ALFF signal value of the right middle frontal gyrus and the left mean RNFL thickness (r=-0.487, P=0.033), and between the mean ALFF signal value of the left middle frontal gyrus and the right mean RNFL thickness (r=-0.504, P=0.020).
Conclusion: PACG mainly involved in the dysfunction in the frontal lobe, which may reflect the underlying pathologic mechanism of PACG.

Keywords: angle-closure glaucoma, amplitude of low-frequency fluctuation, functional magnetic resonance imaging, resting state, spontaneous activity, retinal nerve fiber layer

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Other articles by this author:

Abnormal intrinsic functional hubs in alcohol dependence: evidence from a voxelwise degree centrality analysis

Luo X, Guo LH, Dai XJ, Wang Q, Zhu W, Miao X, Gong H

Neuropsychiatric Disease and Treatment 2017, 13:2011-2020

Published Date: 28 July 2017

Functional connectivity of paired default mode network subregions in primary insomnia

Nie X, Shao Y, Liu SY, Li HJ, Wan AL, Nie S, Peng DC, Dai XJ

Neuropsychiatric Disease and Treatment 2015, 11:3085-3093

Published Date: 16 December 2015

Cerebellar cryptococcosis characterized by a space-occupying lesion in an immunocompetent non-HIV patient

Liu BX, Dai XJ, Liu H, Gong HH, Wang YX, Zhang LL

Neuropsychiatric Disease and Treatment 2015, 11:21-24

Published Date: 19 December 2014

Readers of this article also read:

Emerging and future therapies for hemophilia

Carr ME, Tortella BJ

Journal of Blood Medicine 2015, 6:245-255

Published Date: 3 September 2015

Genetic association between G protein-coupled receptor kinase 6/β-arrestin 2 and dopamine supersensitivity psychosis in schizophrenia

Oda Y, Kanahara N, Kimura H, Watanabe H, Hashimoto K, Iyo M

Neuropsychiatric Disease and Treatment 2015, 11:1845-1851

Published Date: 29 July 2015

Green synthesis of water-soluble nontoxic polymeric nanocomposites containing silver nanoparticles

Prozorova GF, Pozdnyakov AS, Kuznetsova NP, Korzhova SA, Emel’yanov AI, Ermakova TG, Fadeeva TV, Sosedova LM

International Journal of Nanomedicine 2014, 9:1883-1889

Published Date: 16 April 2014

Methacrylic-based nanogels for the pH-sensitive delivery of 5-Fluorouracil in the colon

Ashwanikumar N, Kumar NA, Nair SA, Kumar GS

International Journal of Nanomedicine 2012, 7:5769-5779

Published Date: 15 November 2012

Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy

Deepa G, Thulasidasan AK, Anto RJ, Pillai JJ, Kumar GS

International Journal of Nanomedicine 2012, 7:4077-4088

Published Date: 27 July 2012

Crystallization after intravitreal ganciclovir injection

Pitipol Choopong, Nattaporn Tesavibul, Nattawut Rodanant

Clinical Ophthalmology 2010, 4:709-711

Published Date: 14 July 2010