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Distinguishing Radiation Pneumonitis from Local Tumour Recurrence Following SBRT for Lung Cancer

Authors Frerker B, Hildebrandt G

Received 6 May 2019

Accepted for publication 6 February 2020

Published 9 June 2020 Volume 2020:13 Pages 1—23

DOI https://doi.org/10.2147/RMI.S176901

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Professor Tarik Massoud


Bernd Frerker, Guido Hildebrandt

Department of Radiation Oncology, University Hospital Rostock, Rostock, Germany

Correspondence: Bernd Frerker
Department of Radiation Oncology, University Hospital of Rostock, Südring 75, Rostock 18059, Germany
Tel +49 381 494 9001
Fax +49 381 494 9002
Email bernd.frerker@uni-rostock.de

Abstract: Radiation pneumonitis is one of the most common toxicities following SBRT for lung cancer. Although local control rates are good, a recurrent tumour is difficult to distinguish from radiation pneumonitis due to similar size and morphology. Therefore, early detection of a recurrent tumour is challenging, and moreover, it is crucial for affected patients, as early detection enables curative salvage therapy. Promising data exists to solve these challenges for late recurrences, for example, the analysis of high-risk CT features allows prediction of recurrence after 12 months. But particularly in cases of early recurrences and radiation pneumonitis, comprehensive data are lacking. Therefore, the aim of this study was to review the existing literature with special regard to radiological response assessment after stereotactic body radiotherapy and risk factors for predicting radiation pneumonitis or local recurrence.

Keywords: radiation pneumonitis, tumour recurrence, stereotactic body radiotherapy

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