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Dissolving and biodegradable microneedle technologies for transdermal sustained delivery of drug and vaccine

Authors Hong X, Wei L, Wu F, Wu Z, Chen L, Liu Z, Yuan W

Received 22 February 2013

Accepted for publication 9 May 2013

Published 4 September 2013 Volume 2013:7 Pages 945—952

DOI https://doi.org/10.2147/DDDT.S44401

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Xiaoyun Hong,1,2,* Liangming Wei,3,* Fei Wu,2,* Zaozhan Wu,2 Lizhu Chen,2 Zhenguo Liu,1 Weien Yuan2

1Department of Neurology, Xinhua Hospital, Shanghai, People's Republic of China; 2School of Pharmacy, Shanghai JiaoTong University, Shanghai, People's Republic of China; 3Research Institute of Micro/Nano Science and Technology, Shanghai JiaoTong University, Shanghai, People's Republic of China

*These authors contributed equally to this work

Abstract: Microneedles were first conceptualized for drug delivery many decades ago, overcoming the shortages and preserving the advantages of hypodermic needle and conventional transdermal drug-delivery systems to some extent. Dissolving and biodegradable microneedle technologies have been used for transdermal sustained deliveries of different drugs and vaccines. This review describes microneedle geometry and the representative dissolving and biodegradable microneedle delivery methods via the skin, followed by the fabricating methods. Finally, this review puts forward some perspectives that require further investigation.

Keywords: microneedle, dissolving, biodegradable, sustained release

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