Back to Journals » Drug Design, Development and Therapy » Volume 7
Dissolving and biodegradable microneedle technologies for transdermal sustained delivery of drug and vaccine
Authors Hong X, Wei L, Wu F, Wu Z, Chen L, Liu Z, Yuan W
Received 22 February 2013
Accepted for publication 9 May 2013
Published 4 September 2013 Volume 2013:7 Pages 945—952
DOI https://doi.org/10.2147/DDDT.S44401
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Xiaoyun Hong,1,2,* Liangming Wei,3,* Fei Wu,2,* Zaozhan Wu,2 Lizhu Chen,2 Zhenguo Liu,1 Weien Yuan2
1Department of Neurology, Xinhua Hospital, Shanghai, People's Republic of China; 2School of Pharmacy, Shanghai JiaoTong University, Shanghai, People's Republic of China; 3Research Institute of Micro/Nano Science and Technology, Shanghai JiaoTong University, Shanghai, People's Republic of China
*These authors contributed equally to this work
Abstract: Microneedles were first conceptualized for drug delivery many decades ago, overcoming the shortages and preserving the advantages of hypodermic needle and conventional transdermal drug-delivery systems to some extent. Dissolving and biodegradable microneedle technologies have been used for transdermal sustained deliveries of different drugs and vaccines. This review describes microneedle geometry and the representative dissolving and biodegradable microneedle delivery methods via the skin, followed by the fabricating methods. Finally, this review puts forward some perspectives that require further investigation.
Keywords: microneedle, dissolving, biodegradable, sustained release
© 2013 The Author(s). This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.