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Disrupted Brain Entropy And Functional Connectivity Patterns Of Thalamic Subregions In Major Depressive Disorder

Authors Xue SW, Wang D, Tan Z, Wang Y, Lian Z, Sun Y, Hu X, Wang X, Zhou X

Received 28 June 2019

Accepted for publication 4 September 2019

Published 11 September 2019 Volume 2019:15 Pages 2629—2638

DOI https://doi.org/10.2147/NDT.S220743

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Professor Jun Chen


Shao-Wei Xue,1,2 Donglin Wang,1,2 Zhonglin Tan,3 Yan Wang,1,2 Zhenzhen Lian,1,2 Yunkai Sun,1,2 Xiaojiao Hu,1,2 Xiaole Wang,1,2 Xin Zhou1,2

1Center for Cognition and Brain Disorders, Institutes of Psychological Sciences and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 311121, People’s Republic of China; 2Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou 311121, People’s Republic of China; 3Department of Psychiatry, Hangzhou Seventh People’s Hospital, Hangzhou 310013, People’s Republic of China

Correspondence: Donglin Wang
Center for Cognition and Brain Disorders, Institutes of Psychological Sciences and the Affiliated Hospital, Hangzhou Normal University, 2318 Yuhangtang road, Hangzhou, Zhejiang 311121, People’s Republic of China
Tel +86 571 28867717
Fax +86 571 28867717
Email wangdl@hznu.edu.cn

Purpose: Entropy analysis of resting-state functional magnetic resonance imaging (R-fMRI) has recently been adopted to characterize brain temporal dynamics in some neuropsychological or psychiatric diseases. Thalamus-related dysfunction might be a potential trait marker of major depressive disorder (MDD), but the abnormal changes in the thalamus based on R-fMRI are still unclear from the perspective of brain temporal dynamics. The aim of this study was to identify local entropy changes and subregional connectivity patterns of the thalamus in MDD patients.
Patients and methods: We measured the sample entropy of the R-fMRI data from 46 MDD patients and 32 matched healthy controls. We employed the Louvain method for the module detection algorithm to automatically identify a functional parcellation of the thalamus and then examined the whole-brain subregional connectivity patterns.
Results: The results indicated that the MDD patients had decreased entropy in the bilateral thalami compared with healthy controls. Increased functional connectivity between the thalamic subregions and the medial part of the superior frontal gyrus (mSFG) was found in MDD patients.
Conclusion: This study showed new evidence about sample entropy changes in MDD patients. The functional connectivity alterations that were widely distributed across almost all the thalamic subregions with the mSFG in MDD suggest a general involvement independent of the location and function of the subregions.

Keywords: major depressive disorder, entropy, thalamus, functional connectivity, superior frontal gyrus


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