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Disinfection effects of undoped and silver-doped ceria powders of nanometer crystallite size

Authors Tsai D, Yang T, Huang Y, Peng P, Ou K

Received 6 January 2016

Accepted for publication 1 April 2016

Published 2 June 2016 Volume 2016:11 Pages 2531—2542


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Lei Yang

Dah-Shyang Tsai,1 Tzu-Sen Yang,2,3 Yu-Sheng Huang,1 Pei-Wen Peng,2,4 Keng-Liang Ou3,4

1Department of Chemical Engineering, National Taiwan University of Science and Technology, 2School of Dental Technology, 3Graduate Institute of Biomedical Materials and Tissue Engineering, 4Research Center for Biomedical Implants and Microsurgery Devices, Taipei Medical University, Taipei, Taiwan

Abstract: Being endowed with an ability of capturing and releasing oxygen, the ceria surface conventionally assumes the role of catalyzing redox reactions in chemistry. This catalytic effect also makes possible its cytotoxicity toward microorganisms at room temperature. To study this cytotoxicity, we synthesized the doped and undoped ceria particles of 8–9 nm in size using an inexpensive precipitation method and evaluated their disinfecting aptitudes with the turbidimetric and plate count methods. Among the samples being analyzed, the silver-doped ceria exhibits the highest sterilization ability, yet the undoped ceria is the most intriguing. The disinfection effect of undoped ceria is moderate in magnitude, demanding a physical contact between the ceria surface and bacteria cell wall, or the redox catalysis that can damage the cell wall and result in the cell killing. Evidently, this effect is short-range and depends strongly on dispersion of the nanoparticles. In contrast, the disinfection effects of silver-doped ceria reach out several millimeters since it releases silver ions to poison the surrounding microorganisms. Additionally, the aliovalent silver substitution creates more ceria defects. The synergetic combination, silver poisoning and heterogeneous redox catalysis, lifts and extends the disinfecting capability of silver-doped ceria to a superior level.

Keywords: ceria nanoparticle, antibacterial activity, cytotoxicity, oxygen vacancy, reactive oxygen species

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